| pubmed-article:2010174 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2010174 | lifeskim:mentions | umls-concept:C0596972 | lld:lifeskim |
| pubmed-article:2010174 | lifeskim:mentions | umls-concept:C1280551 | lld:lifeskim |
| pubmed-article:2010174 | lifeskim:mentions | umls-concept:C0205054 | lld:lifeskim |
| pubmed-article:2010174 | lifeskim:mentions | umls-concept:C0032716 | lld:lifeskim |
| pubmed-article:2010174 | lifeskim:mentions | umls-concept:C0010592 | lld:lifeskim |
| pubmed-article:2010174 | lifeskim:mentions | umls-concept:C0449438 | lld:lifeskim |
| pubmed-article:2010174 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2010174 | lifeskim:mentions | umls-concept:C1442080 | lld:lifeskim |
| pubmed-article:2010174 | lifeskim:mentions | umls-concept:C1156451 | lld:lifeskim |
| pubmed-article:2010174 | lifeskim:mentions | umls-concept:C0877853 | lld:lifeskim |
| pubmed-article:2010174 | lifeskim:mentions | umls-concept:C1521743 | lld:lifeskim |
| pubmed-article:2010174 | lifeskim:mentions | umls-concept:C0181904 | lld:lifeskim |
| pubmed-article:2010174 | lifeskim:mentions | umls-concept:C1704646 | lld:lifeskim |
| pubmed-article:2010174 | lifeskim:mentions | umls-concept:C0728873 | lld:lifeskim |
| pubmed-article:2010174 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:2010174 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2010174 | pubmed:dateCreated | 1991-5-9 | lld:pubmed |
| pubmed-article:2010174 | pubmed:abstractText | The effect of cyclosporin A on the hepatic energy status and intracellular pH of the liver and its response to a fructose challenge has been investigated using in vivo phosphorus-31 nuclear magnetic resonance spectroscopy in dogs. Three experimental groups were studied: (a) control dogs (n = 5), (b) dogs 4 days after the creation of an end-to-side portacaval shunt (n = 5), and (c) dogs 4 days after portacaval shunt and continuous infusion of cyclosporin A (4 mg/kg/day) by way of the left portal vein (portacaval shunt plus cyclosporin A, n = 5). The phosphorus-31 nuclear magnetic resonance spectra were obtained at 81 MHz using a Bruker BIOSPEC II 4.7-tesla nuclear magnetic resonance system equipped with a 40-cm horizontal bore superconducting solenoid. The phosphomonoesters (p less than 0.01), inorganic phosphate and ATP levels (p less than 0.05) were decreased significantly in portacaval shunt-treated and in portacaval shunt-plus-cyclosporin A-treated dogs compared with unshunted control dogs. After a fructose challenge (750 mg/kg body wt, intravenously), fructose-1-phosphate metabolism was reduced in portacaval shunt-treated dogs compared with either the normal or portacaval shunt-plus-cyclosporin A-treated dogs (p less than 0.05). Both portacaval shunt- and portacaval shunt-plus-cyclosporin A-treated dogs demonstrated a reduced decline in ATP levels after fructose infusion when compared with the controls (p less than 0.05). Immediately after the fructose challenge, the intracellular pH decreased from 7.30 +/- 0.03 to 7.00 +/- 0.05 in all animals (p less than 0.01) and then gradually returned to normal over 60 min.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:2010174 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2010174 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2010174 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2010174 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2010174 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2010174 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2010174 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2010174 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2010174 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2010174 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2010174 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2010174 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2010174 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2010174 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2010174 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2010174 | pubmed:issn | 0270-9139 | lld:pubmed |
| pubmed-article:2010174 | pubmed:author | pubmed-author:Van ThielD... | lld:pubmed |
| pubmed-article:2010174 | pubmed:author | pubmed-author:HoCC | lld:pubmed |
| pubmed-article:2010174 | pubmed:author | pubmed-author:StarzlT ETE | lld:pubmed |
| pubmed-article:2010174 | pubmed:author | pubmed-author:FrancavillaAA | lld:pubmed |
| pubmed-article:2010174 | pubmed:author | pubmed-author:WilliamsD SDS | lld:pubmed |
| pubmed-article:2010174 | pubmed:author | pubmed-author:MazzaferroVV | lld:pubmed |
| pubmed-article:2010174 | pubmed:author | pubmed-author:RossaroLL | lld:pubmed |
| pubmed-article:2010174 | pubmed:author | pubmed-author:SimplaceanuVV | lld:pubmed |
| pubmed-article:2010174 | pubmed:author | pubmed-author:SimplaceanuEE | lld:pubmed |
| pubmed-article:2010174 | pubmed:author | pubmed-author:Scotti-Foglie... | lld:pubmed |
| pubmed-article:2010174 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2010174 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:2010174 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2010174 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2010174 | pubmed:pagination | 780-5 | lld:pubmed |
| pubmed-article:2010174 | pubmed:dateRevised | 2010-12-3 | lld:pubmed |
| pubmed-article:2010174 | pubmed:meshHeading | pubmed-meshheading:2010174-... | lld:pubmed |
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| pubmed-article:2010174 | pubmed:meshHeading | pubmed-meshheading:2010174-... | lld:pubmed |
| pubmed-article:2010174 | pubmed:meshHeading | pubmed-meshheading:2010174-... | lld:pubmed |
| pubmed-article:2010174 | pubmed:meshHeading | pubmed-meshheading:2010174-... | lld:pubmed |
| pubmed-article:2010174 | pubmed:meshHeading | pubmed-meshheading:2010174-... | lld:pubmed |
| pubmed-article:2010174 | pubmed:meshHeading | pubmed-meshheading:2010174-... | lld:pubmed |
| pubmed-article:2010174 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:2010174 | pubmed:articleTitle | Effect of cyclosporine on hepatic energy status and on fructose metabolism after portacaval shunt in dog as monitored by phosphorus-31 nuclear magnetic resonance spectroscopy in vivo. | lld:pubmed |
| pubmed-article:2010174 | pubmed:affiliation | Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania 15261. | lld:pubmed |
| pubmed-article:2010174 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2010174 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2010174 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:2010174 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2010174 | lld:pubmed |
