| pubmed-article:2010046 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2010046 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:2010046 | lifeskim:mentions | umls-concept:C0011853 | lld:lifeskim |
| pubmed-article:2010046 | lifeskim:mentions | umls-concept:C0012155 | lld:lifeskim |
| pubmed-article:2010046 | lifeskim:mentions | umls-concept:C0022663 | lld:lifeskim |
| pubmed-article:2010046 | lifeskim:mentions | umls-concept:C0019010 | lld:lifeskim |
| pubmed-article:2010046 | lifeskim:mentions | umls-concept:C0021547 | lld:lifeskim |
| pubmed-article:2010046 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:2010046 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:2010046 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2010046 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:2010046 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2010046 | pubmed:dateCreated | 1991-5-6 | lld:pubmed |
| pubmed-article:2010046 | pubmed:abstractText | Early functional disturbances in nerve, retina, and lens in diabetes mellitus appear to result from a common mechanism involving increased polyol-pathway activity with an associated effect on tissue myo-inositol metabolism. We tested the role of increased polyol-pathway activity in the early glomerular hemodynamic abnormalities in experimental diabetes in rats with dietary myo-inositol supplementation or the administration of sorbinil, an aldose reductase inhibitor. Each maneuver prevented the glomerular hyperfiltration of early streptozocin-induced diabetes and reversed the hyperfiltration of established diabetes of 10 days' duration. We also found that the abnormal response to captopril in diabetic rats was improved by dietary myo-inositol supplementation or sorbinil administration. Although nonhypotensive doses of captopril lowered glomerular filtration rate (GFR) in diabetic rats on a 0.01% myo-inositol diet, GFR increased substantially after captopril infusion in diabetic rats treated with sorbinil or myo-inositol supplementation. These data suggest that normalization of tissue myo-inositol metabolism restores normal responsiveness to angiotensin II; this may contribute to the reduction in GFR with the two experimental maneuvers. We also tested the interaction between polyol-pathway activation and high dietary protein intake. Aldose reductase inhibition and dietary myo-inositol supplementation had no effect on the component of increased GFR due to 50% dietary protein intake but specifically inhibited the hyperfiltration attributable to diabetes. These results suggest that hyperglycemia acts through increased polyol-pathway activity and its effects on tissue myo-inositol metabolism to play a fundamental role in the pathogenesis of the glomerular hyperfiltration characteristic of early diabetes. | lld:pubmed |
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| pubmed-article:2010046 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2010046 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:2010046 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2010046 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2010046 | pubmed:issn | 0012-1797 | lld:pubmed |
| pubmed-article:2010046 | pubmed:author | pubmed-author:GoldfarbSS | lld:pubmed |
| pubmed-article:2010046 | pubmed:author | pubmed-author:SimmonsD ADA | lld:pubmed |
| pubmed-article:2010046 | pubmed:author | pubmed-author:ZiyadehF NFN | lld:pubmed |
| pubmed-article:2010046 | pubmed:author | pubmed-author:KernE FEF | lld:pubmed |
| pubmed-article:2010046 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2010046 | pubmed:volume | 40 | lld:pubmed |
| pubmed-article:2010046 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2010046 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2010046 | pubmed:pagination | 465-71 | lld:pubmed |
| pubmed-article:2010046 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:2010046 | pubmed:meshHeading | pubmed-meshheading:2010046-... | lld:pubmed |
| pubmed-article:2010046 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:2010046 | pubmed:articleTitle | Effects of polyol-pathway inhibition and dietary myo-inositol on glomerular hemodynamic function in experimental diabetes mellitus in rats. | lld:pubmed |
| pubmed-article:2010046 | pubmed:affiliation | Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-6144. | lld:pubmed |
| pubmed-article:2010046 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2010046 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2010046 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2010046 | lld:pubmed |
