| pubmed-article:20097678 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20097678 | lifeskim:mentions | umls-concept:C0005910 | lld:lifeskim |
| pubmed-article:20097678 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:20097678 | lifeskim:mentions | umls-concept:C0021665 | lld:lifeskim |
| pubmed-article:20097678 | lifeskim:mentions | umls-concept:C1415504 | lld:lifeskim |
| pubmed-article:20097678 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:20097678 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:20097678 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:20097678 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:20097678 | pubmed:dateCreated | 2010-3-29 | lld:pubmed |
| pubmed-article:20097678 | pubmed:abstractText | Levels of full-length huntingtin (FL htt) influence organ and body weight, independent of polyglutamine length. The growth hormone-insulin like growth factor-1 (GH-IGF-1) axis is well established as a regulator of organ growth and body weight. In this study, we investigate the involvement of the IGF-1 pathway in mediating the effect of htt on body weight. IGF-1 expression was examined in transgenic mouse lines expressing different levels of FL wild-type (WT) htt (YAC18 mice), FL mutant htt (YAC128 and BACHD mice) and truncated mutant htt (shortstop mice). We demonstrate that htt influences body weight by modulating the IGF-1 pathway. Plasma IGF-1 levels correlate with body weight and htt levels in the transgenic YAC mice expressing human htt. The effect of htt on IGF-1 expression is independent of CAG size. No effect on body weight is observed in transgenic YAC mice expressing a truncated N-terminal htt fragment (shortstop), indicating that FL htt is required for the modulation of IGF-1 expression. Treatment with 17beta-estradiol (17beta-ED) lowers the levels of circulating IGF-1 in mammals. Treatment of YAC128 with 17beta-ED, but not placebo, reduces plasma IGF-1 levels and decreases the body weight of YAC128 animals to WT levels. Furthermore, given the ubiquitous expression of IGF-1 within the central nervous system, we also examined the impact of FL htt levels on IGF-1 expression in different regions of the brain, including the striatum, cerebellum of YAC18, YAC128 and littermate WT mice. We demonstrate that the levels of FL htt influence IGF-1 expression in striatal tissues. Our data identify a novel function for FL htt in influencing IGF-1 expression. | lld:pubmed |
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| pubmed-article:20097678 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20097678 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20097678 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20097678 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20097678 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20097678 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:20097678 | pubmed:issn | 1460-2083 | lld:pubmed |
| pubmed-article:20097678 | pubmed:author | pubmed-author:HaydenMichael... | lld:pubmed |
| pubmed-article:20097678 | pubmed:author | pubmed-author:LeavittBlair... | lld:pubmed |
| pubmed-article:20097678 | pubmed:author | pubmed-author:BissadaNagatN | lld:pubmed |
| pubmed-article:20097678 | pubmed:author | pubmed-author:FriedlanderRo... | lld:pubmed |
| pubmed-article:20097678 | pubmed:author | pubmed-author:PaganettiPaol... | lld:pubmed |
