| pubmed-article:20085707 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20085707 | lifeskim:mentions | umls-concept:C0682323 | lld:lifeskim |
| pubmed-article:20085707 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:20085707 | lifeskim:mentions | umls-concept:C1704410 | lld:lifeskim |
| pubmed-article:20085707 | lifeskim:mentions | umls-concept:C0205470 | lld:lifeskim |
| pubmed-article:20085707 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:20085707 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:20085707 | pubmed:dateCreated | 2010-1-20 | lld:pubmed |
| pubmed-article:20085707 | pubmed:abstractText | Aire induces the expression of a battery of peripheral-tissue self-antigens (PTAs) in thymic stromal cells, promoting the clonal deletion of differentiating T cells that recognize them. Just how Aire targets and induces PTA transcripts remains largely undefined. Screening via Aire-targeted coimmunoprecipitation followed by mass spectrometry, and validating by multiple RNAi-mediated knockdown approaches, we identified a large set of proteins that associate with Aire. They fall into four major functional classes: nuclear transport, chromatin binding/structure, transcription and pre-mRNA processing. One set of Aire interactions centered on DNA protein kinase and a group of proteins it partners with to resolve DNA double-stranded breaks or promote transcriptional elongation. Another set of interactions was focused on the pre-mRNA splicing and maturation machinery, potentially explaining the markedly more effective processing of PTA transcripts in the presence of Aire. These findings suggest a model to explain Aire's widespread targeting and induction of weakly transcribed chromatin regions. | lld:pubmed |
| pubmed-article:20085707 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20085707 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:20085707 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20085707 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20085707 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:20085707 | pubmed:issn | 1097-4172 | lld:pubmed |
| pubmed-article:20085707 | pubmed:author | pubmed-author:BenoistChrist... | lld:pubmed |
| pubmed-article:20085707 | pubmed:author | pubmed-author:MathisDianeD | lld:pubmed |
| pubmed-article:20085707 | pubmed:author | pubmed-author:AbramsonJakub... | lld:pubmed |
| pubmed-article:20085707 | pubmed:author | pubmed-author:GiraudMatthie... | lld:pubmed |
| pubmed-article:20085707 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20085707 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:20085707 | pubmed:volume | 140 | lld:pubmed |
| pubmed-article:20085707 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20085707 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20085707 | pubmed:pagination | 123-35 | lld:pubmed |
| pubmed-article:20085707 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:20085707 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20085707 | pubmed:articleTitle | Aire's partners in the molecular control of immunological tolerance. | lld:pubmed |
| pubmed-article:20085707 | pubmed:affiliation | Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. | lld:pubmed |
| pubmed-article:20085707 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20085707 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:20085707 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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