Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry.
Source:http://linkedlifedata.com/resource/pubmed/id/20085328
J. Med. Chem.
2010
Feb
11
53
3
1306-18
