Mouse Prkar1a haploinsufficiency leads to an increase in tumors in the Trp53+/- or Rb1+/- backgrounds and chemically induced skin papillomas by dysregulation of the cell cycle and Wnt signaling.

Source:http://linkedlifedata.com/resource/pubmed/id/20080939

Hum. Mol. Genet. 2010 Apr 15 19 8 1387-98

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20080939