| pubmed-article:20080201 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20080201 | lifeskim:mentions | umls-concept:C0008972 | lld:lifeskim |
| pubmed-article:20080201 | lifeskim:mentions | umls-concept:C0024117 | lld:lifeskim |
| pubmed-article:20080201 | lifeskim:mentions | umls-concept:C0178602 | lld:lifeskim |
| pubmed-article:20080201 | lifeskim:mentions | umls-concept:C0036576 | lld:lifeskim |
| pubmed-article:20080201 | lifeskim:mentions | umls-concept:C1707689 | lld:lifeskim |
| pubmed-article:20080201 | lifeskim:mentions | umls-concept:C1722262 | lld:lifeskim |
| pubmed-article:20080201 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:20080201 | pubmed:dateCreated | 2010-4-7 | lld:pubmed |
| pubmed-article:20080201 | pubmed:abstractText | The drug development process can be streamlined by combining the traditionally separate stages of dose-finding (Phase IIb) and confirmation of efficacy and safety (Phase III) using an adaptive seamless design. This approach was used in a clinical study of indacaterol, a novel once-daily (od) inhaled long-acting beta(2)-adrenoreceptor agonist bronchodilator for the treatment of COPD (chronic obstructive pulmonary disease). | lld:pubmed |
| pubmed-article:20080201 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20080201 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20080201 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20080201 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20080201 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20080201 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20080201 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20080201 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20080201 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20080201 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20080201 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20080201 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20080201 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:20080201 | pubmed:issn | 1522-9629 | lld:pubmed |
| pubmed-article:20080201 | pubmed:author | pubmed-author:BarnesPeter... | lld:pubmed |
| pubmed-article:20080201 | pubmed:author | pubmed-author:LawrenceDavid... | lld:pubmed |
| pubmed-article:20080201 | pubmed:author | pubmed-author:MagnussenHelg... | lld:pubmed |
| pubmed-article:20080201 | pubmed:author | pubmed-author:PocockStuart... | lld:pubmed |
| pubmed-article:20080201 | pubmed:author | pubmed-author:KramerBenjami... | lld:pubmed |
| pubmed-article:20080201 | pubmed:author | pubmed-author:HigginsMarkM | lld:pubmed |
| pubmed-article:20080201 | pubmed:author | pubmed-author:IqbalAmirA | lld:pubmed |
| pubmed-article:20080201 | pubmed:copyrightInfo | Copyright 2010 Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:20080201 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20080201 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:20080201 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20080201 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20080201 | pubmed:pagination | 165-71 | lld:pubmed |
| pubmed-article:20080201 | pubmed:meshHeading | pubmed-meshheading:20080201... | lld:pubmed |
| pubmed-article:20080201 | pubmed:meshHeading | pubmed-meshheading:20080201... | lld:pubmed |
| pubmed-article:20080201 | pubmed:meshHeading | pubmed-meshheading:20080201... | lld:pubmed |
| pubmed-article:20080201 | pubmed:meshHeading | pubmed-meshheading:20080201... | lld:pubmed |
| pubmed-article:20080201 | pubmed:meshHeading | pubmed-meshheading:20080201... | lld:pubmed |
| pubmed-article:20080201 | pubmed:meshHeading | pubmed-meshheading:20080201... | lld:pubmed |
| pubmed-article:20080201 | pubmed:meshHeading | pubmed-meshheading:20080201... | lld:pubmed |
| pubmed-article:20080201 | pubmed:meshHeading | pubmed-meshheading:20080201... | lld:pubmed |
| pubmed-article:20080201 | pubmed:meshHeading | pubmed-meshheading:20080201... | lld:pubmed |
| pubmed-article:20080201 | pubmed:meshHeading | pubmed-meshheading:20080201... | lld:pubmed |
| pubmed-article:20080201 | pubmed:meshHeading | pubmed-meshheading:20080201... | lld:pubmed |
| pubmed-article:20080201 | pubmed:meshHeading | pubmed-meshheading:20080201... | lld:pubmed |
| pubmed-article:20080201 | pubmed:meshHeading | pubmed-meshheading:20080201... | lld:pubmed |
| pubmed-article:20080201 | pubmed:meshHeading | pubmed-meshheading:20080201... | lld:pubmed |
| pubmed-article:20080201 | pubmed:meshHeading | pubmed-meshheading:20080201... | lld:pubmed |
| pubmed-article:20080201 | pubmed:meshHeading | pubmed-meshheading:20080201... | lld:pubmed |
| pubmed-article:20080201 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20080201 | pubmed:articleTitle | Integrating indacaterol dose selection in a clinical study in COPD using an adaptive seamless design. | lld:pubmed |
| pubmed-article:20080201 | pubmed:affiliation | Imperial College, London, UK. p.j.barnes@imperial.ac.uk | lld:pubmed |
| pubmed-article:20080201 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20080201 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:20080201 | pubmed:publicationType | Clinical Trial, Phase II | lld:pubmed |
| pubmed-article:20080201 | pubmed:publicationType | Clinical Trial, Phase III | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:20080201 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:20080201 | lld:pubmed |
