| pubmed-article:20079560 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20079560 | lifeskim:mentions | umls-concept:C0002062 | lld:lifeskim |
| pubmed-article:20079560 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:20079560 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:20079560 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:20079560 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:20079560 | lifeskim:mentions | umls-concept:C0445223 | lld:lifeskim |
| pubmed-article:20079560 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:20079560 | lifeskim:mentions | umls-concept:C1552599 | lld:lifeskim |
| pubmed-article:20079560 | lifeskim:mentions | umls-concept:C1704787 | lld:lifeskim |
| pubmed-article:20079560 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:20079560 | lifeskim:mentions | umls-concept:C0001046 | lld:lifeskim |
| pubmed-article:20079560 | lifeskim:mentions | umls-concept:C0073716 | lld:lifeskim |
| pubmed-article:20079560 | lifeskim:mentions | umls-concept:C0243072 | lld:lifeskim |
| pubmed-article:20079560 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:20079560 | pubmed:dateCreated | 2010-3-8 | lld:pubmed |
| pubmed-article:20079560 | pubmed:abstractText | A series of novel rutaecarpine derivatives and related alkaloid derivatives 3-aminoalkanamido-substituted rutaecarpine 4a-f and 7,8-dehydrorutaecarpine 5a-c, and 6-aminoalkanamido-substituted 3-[2-(3-Indolyl)ethyl]-4(3a)-quinazolinones 8a-c, were synthesized and subjected to pharmacological evaluation as acetylcholinesterase (AChE) inhibitors. The synthetic compounds exhibited strong inhibitory activity for AChE and high selectivity for AChE over BuChE. The structure-activity relationships were discussed and their binding conformation and simultaneous interactions mode were further clarified by kinetic characterization and the molecular docking studies. | lld:pubmed |
| pubmed-article:20079560 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20079560 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20079560 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20079560 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20079560 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20079560 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20079560 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20079560 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20079560 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20079560 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20079560 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:20079560 | pubmed:issn | 1768-3254 | lld:pubmed |
| pubmed-article:20079560 | pubmed:author | pubmed-author:WoodR WRW | lld:pubmed |
| pubmed-article:20079560 | pubmed:author | pubmed-author:LiYueY | lld:pubmed |
| pubmed-article:20079560 | pubmed:author | pubmed-author:DingLiL | lld:pubmed |
| pubmed-article:20079560 | pubmed:author | pubmed-author:GuLian-QuanLQ | lld:pubmed |
| pubmed-article:20079560 | pubmed:author | pubmed-author:HuangZhi-ShuZ... | lld:pubmed |
| pubmed-article:20079560 | pubmed:author | pubmed-author:AnLin-KunLK | lld:pubmed |
| pubmed-article:20079560 | pubmed:author | pubmed-author:OuTian-MiaoTM | lld:pubmed |
| pubmed-article:20079560 | pubmed:author | pubmed-author:TanJia-HengJH | lld:pubmed |
| pubmed-article:20079560 | pubmed:author | pubmed-author:HuangShi-Lian... | lld:pubmed |
| pubmed-article:20079560 | pubmed:author | pubmed-author:HouJin-QiangJ... | lld:pubmed |
| pubmed-article:20079560 | pubmed:author | pubmed-author:MaiYi-ChiYC | lld:pubmed |
| pubmed-article:20079560 | pubmed:copyrightInfo | Copyright (c) 2009 Elsevier Masson SAS. All rights reserved. | lld:pubmed |
| pubmed-article:20079560 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20079560 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:20079560 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20079560 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20079560 | pubmed:pagination | 1415-23 | lld:pubmed |
| pubmed-article:20079560 | pubmed:meshHeading | pubmed-meshheading:20079560... | lld:pubmed |
| pubmed-article:20079560 | pubmed:meshHeading | pubmed-meshheading:20079560... | lld:pubmed |
| pubmed-article:20079560 | pubmed:meshHeading | pubmed-meshheading:20079560... | lld:pubmed |
| pubmed-article:20079560 | pubmed:meshHeading | pubmed-meshheading:20079560... | lld:pubmed |
| pubmed-article:20079560 | pubmed:meshHeading | pubmed-meshheading:20079560... | lld:pubmed |
| pubmed-article:20079560 | pubmed:meshHeading | pubmed-meshheading:20079560... | lld:pubmed |
| pubmed-article:20079560 | pubmed:meshHeading | pubmed-meshheading:20079560... | lld:pubmed |
| pubmed-article:20079560 | pubmed:meshHeading | pubmed-meshheading:20079560... | lld:pubmed |
| pubmed-article:20079560 | pubmed:meshHeading | pubmed-meshheading:20079560... | lld:pubmed |
| pubmed-article:20079560 | pubmed:meshHeading | pubmed-meshheading:20079560... | lld:pubmed |
| pubmed-article:20079560 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20079560 | pubmed:articleTitle | Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors. | lld:pubmed |
| pubmed-article:20079560 | pubmed:affiliation | School of Pharmaceutical Sciences, Sun Yat-sen University, Waihuan East Road 132, Guangzhou 510006, People's Republic of China. | lld:pubmed |
| pubmed-article:20079560 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20079560 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:20079560 | lld:chembl |
