| pubmed-article:20074534 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20074534 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:20074534 | lifeskim:mentions | umls-concept:C0018956 | lld:lifeskim |
| pubmed-article:20074534 | lifeskim:mentions | umls-concept:C0231449 | lld:lifeskim |
| pubmed-article:20074534 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:20074534 | pubmed:dateCreated | 2010-1-15 | lld:pubmed |
| pubmed-article:20074534 | pubmed:abstractText | Sustained blood cell production depends on divisions by hematopoietic stem cells (HSCs) that yield both differentiating progeny as well as new HSCs via self-renewal. Differentiating progeny remain capable of self-renewal, but only HSCs sustain self-renewal through successive divisions securely enough to maintain clones that persist life-long. Until recently, the first identified next stage consisted of "short-term" reconstituting cells able to sustain clones of differentiating cells for only 4-6 weeks. Here we expand evidence for a numerically dominant "intermediate-term" multipotent HSC stage in mice whose clones persist for 6-8 months before becoming extinct and that are separable from both short-term as well as permanently reconstituting "long-term" HSCs. The findings suggest that the first step in stem cell differentiation consists not in loss of initial capacity for serial self-renewal divisions, but rather in loss of mechanisms that stabilize self-renewing behavior throughout successive future stem cell divisions. | lld:pubmed |
| pubmed-article:20074534 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074534 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20074534 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074534 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20074534 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074534 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074534 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074534 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074534 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074534 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074534 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074534 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20074534 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:20074534 | pubmed:issn | 1875-9777 | lld:pubmed |
| pubmed-article:20074534 | pubmed:author | pubmed-author:BenvenistePat... | lld:pubmed |
| pubmed-article:20074534 | pubmed:author | pubmed-author:IscoveNorman... | lld:pubmed |
| pubmed-article:20074534 | pubmed:author | pubmed-author:FrelinCatheri... | lld:pubmed |
| pubmed-article:20074534 | pubmed:author | pubmed-author:BarbaraMaryM | lld:pubmed |
| pubmed-article:20074534 | pubmed:author | pubmed-author:HyamDeborahD | lld:pubmed |
| pubmed-article:20074534 | pubmed:author | pubmed-author:HerringtonRob... | lld:pubmed |
| pubmed-article:20074534 | pubmed:author | pubmed-author:JanmohamedSal... | lld:pubmed |
| pubmed-article:20074534 | pubmed:copyrightInfo | Copyright 2010 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:20074534 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20074534 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:20074534 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:20074534 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20074534 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20074534 | pubmed:pagination | 48-58 | lld:pubmed |
| pubmed-article:20074534 | pubmed:meshHeading | pubmed-meshheading:20074534... | lld:pubmed |
| pubmed-article:20074534 | pubmed:meshHeading | pubmed-meshheading:20074534... | lld:pubmed |
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| pubmed-article:20074534 | pubmed:meshHeading | pubmed-meshheading:20074534... | lld:pubmed |
| pubmed-article:20074534 | pubmed:meshHeading | pubmed-meshheading:20074534... | lld:pubmed |
| pubmed-article:20074534 | pubmed:meshHeading | pubmed-meshheading:20074534... | lld:pubmed |
| pubmed-article:20074534 | pubmed:meshHeading | pubmed-meshheading:20074534... | lld:pubmed |
| pubmed-article:20074534 | pubmed:meshHeading | pubmed-meshheading:20074534... | lld:pubmed |
| pubmed-article:20074534 | pubmed:meshHeading | pubmed-meshheading:20074534... | lld:pubmed |
| pubmed-article:20074534 | pubmed:meshHeading | pubmed-meshheading:20074534... | lld:pubmed |
| pubmed-article:20074534 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20074534 | pubmed:articleTitle | Intermediate-term hematopoietic stem cells with extended but time-limited reconstitution potential. | lld:pubmed |
| pubmed-article:20074534 | pubmed:affiliation | Ontario Cancer Institute, Toronto, ON M5G 2M9, Canada. | lld:pubmed |
| pubmed-article:20074534 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20074534 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:20074534 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:14751 | entrezgene:pubmed | pubmed-article:20074534 | lld:entrezgene |
| entrez-gene:16590 | entrezgene:pubmed | pubmed-article:20074534 | lld:entrezgene |
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