| pubmed-article:20074280 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20074280 | lifeskim:mentions | umls-concept:C0035435 | lld:lifeskim |
| pubmed-article:20074280 | lifeskim:mentions | umls-concept:C0021755 | lld:lifeskim |
| pubmed-article:20074280 | lifeskim:mentions | umls-concept:C0332206 | lld:lifeskim |
| pubmed-article:20074280 | pubmed:dateCreated | 2010-1-15 | lld:pubmed |
| pubmed-article:20074280 | pubmed:abstractText | The role of the potent proinflammatory cytokine IL-1 in disease could clinically be investigated with the development of the IL-1 blocking agent anakinra (Kineret), a recombinant IL-1 receptor antagonist. It was first tested in patients with sepsis without much benefit but was later FDA approved for the treatment of patients with rheumatoid arthritis. More recently IL-1 blocking therapies are used successfully to treat a new group of immune-mediated inflammatory conditions, autoinflammatory diseases. These conditions include rare hereditary fever syndromes and pediatric and adult conditions of Still's disease. Recently the FDA approved two additional longer acting IL-1 blocking agents, for the treatment of cryopyrin-associated periodic syndromes (CAPS), an IL-1 dependent autoinflammatory syndrome. The study of autoinflammatory diseases revealed mechanisms of IL-1 mediated organ damage and provided concepts to a better understanding of the pathogenesis of more common diseases such as gout and Type 2 diabetes which show initial promising results with IL-1 blocking therapy. | lld:pubmed |
| pubmed-article:20074280 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20074280 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20074280 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20074280 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20074280 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:20074280 | pubmed:issn | 1749-6632 | lld:pubmed |
| pubmed-article:20074280 | pubmed:author | pubmed-author:Goldbach-Mans... | lld:pubmed |
| pubmed-article:20074280 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20074280 | pubmed:volume | 1182 | lld:pubmed |
| pubmed-article:20074280 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20074280 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20074280 | pubmed:pagination | 111-23 | lld:pubmed |
| pubmed-article:20074280 | pubmed:dateRevised | 2011-7-28 | lld:pubmed |
| pubmed-article:20074280 | pubmed:meshHeading | pubmed-meshheading:20074280... | lld:pubmed |
| pubmed-article:20074280 | pubmed:meshHeading | pubmed-meshheading:20074280... | lld:pubmed |
| pubmed-article:20074280 | pubmed:meshHeading | pubmed-meshheading:20074280... | lld:pubmed |
| pubmed-article:20074280 | pubmed:meshHeading | pubmed-meshheading:20074280... | lld:pubmed |
| pubmed-article:20074280 | pubmed:meshHeading | pubmed-meshheading:20074280... | lld:pubmed |
| pubmed-article:20074280 | pubmed:meshHeading | pubmed-meshheading:20074280... | lld:pubmed |
| pubmed-article:20074280 | pubmed:meshHeading | pubmed-meshheading:20074280... | lld:pubmed |
| pubmed-article:20074280 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:20074280 | pubmed:articleTitle | Blocking interleukin-1 in rheumatic diseases. | lld:pubmed |
| pubmed-article:20074280 | pubmed:affiliation | National Institute of Arthritis and Musculoskeletal and Skin Diseases at the National Institutes of Health, Bethesda, Maryland 20892, USA. goldbacr@mail.nih.gov | lld:pubmed |
| pubmed-article:20074280 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:20074280 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:20074280 | lld:pubmed |
