| pubmed-article:20071663 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20071663 | lifeskim:mentions | umls-concept:C0023493 | lld:lifeskim |
| pubmed-article:20071663 | lifeskim:mentions | umls-concept:C1421244 | lld:lifeskim |
| pubmed-article:20071663 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:20071663 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:20071663 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:20071663 | pubmed:dateCreated | 2010-9-8 | lld:pubmed |
| pubmed-article:20071663 | pubmed:abstractText | Adult T-cell leukemia (ATL) is a T-cell malignancy etiologically associated with human T-cell leukemia virus type 1 (HTLV-1). Twist, a highly conserved basic helix-loop-helix transcription factor, is a newly identified oncogene. However, there are no reports on Twist expression in ATL. To define the role of Twist in leukemogenesis of ATL, we examined its expression in T-cell lines and PBMC. HTLV-1-infected T-cell lines and ATL cells expressed high levels of Twist compared with uninfected T-cell lines and normal PBMC. Immunohistochemistry showed immunostaining for Twist in ATL cells in ATL lymph nodes and skin lesions. Infection of normal PBMC with HTLV-1 induced Twist expression. Induction of the viral protein Tax in a human T-cell line led to upregulation of Twist. Tax-induced Twist expression involved the NF-kappaB and CREB signaling pathways. Twist augmented Tax-mediated HTLV-1 LTR and NF-kappaB activation. Short interfering RNA against Twist inhibited cell growth of HTLV-1-infected T-cell lines and downregulation of Twist expression in an HTLV-1-infected T-cell line inhibited the expression of Akt1, interleukin-2 receptor alpha chain, and Tax as well as the known target genes of Twist, YB-1 and Akt2. In conclusion, the results suggest that Tax-induced induction of Twist contributes to leukemogenesis of ATL. | lld:pubmed |
| pubmed-article:20071663 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20071663 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20071663 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20071663 | pubmed:status | PubMed-not-MEDLINE | lld:pubmed |
| pubmed-article:20071663 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:20071663 | pubmed:issn | 1528-0020 | lld:pubmed |
| pubmed-article:20071663 | pubmed:author | pubmed-author:TanakaYuetsuY | lld:pubmed |
| pubmed-article:20071663 | pubmed:author | pubmed-author:MoriNaokiN | lld:pubmed |
| pubmed-article:20071663 | pubmed:author | pubmed-author:SenbaMasachik... | lld:pubmed |
| pubmed-article:20071663 | pubmed:author | pubmed-author:SawadaShigeki... | lld:pubmed |
| pubmed-article:20071663 | pubmed:author | pubmed-author:OhshimaKoichi... | lld:pubmed |
| pubmed-article:20071663 | pubmed:author | pubmed-author:UezatoHiroshi... | lld:pubmed |
| pubmed-article:20071663 | pubmed:author | pubmed-author:WuKou-JueyKJ | lld:pubmed |
| pubmed-article:20071663 | pubmed:author | pubmed-author:OkudairaTaeko... | lld:pubmed |
| pubmed-article:20071663 | pubmed:author | pubmed-author:MatsudaTakehi... | lld:pubmed |
| pubmed-article:20071663 | pubmed:author | pubmed-author:UchiharaJun-N... | lld:pubmed |
| pubmed-article:20071663 | pubmed:author | pubmed-author:OhshiroKazuik... | lld:pubmed |
| pubmed-article:20071663 | pubmed:author | pubmed-author:Duc... | lld:pubmed |
| pubmed-article:20071663 | pubmed:author | pubmed-author:IshikawaChieC | lld:pubmed |
| pubmed-article:20071663 | pubmed:author | pubmed-author:TakamatsuReik... | lld:pubmed |
| pubmed-article:20071663 | pubmed:author | pubmed-author:NakachiSawako... | lld:pubmed |
| pubmed-article:20071663 | pubmed:author | pubmed-author:TanjiHiroeH | lld:pubmed |
| pubmed-article:20071663 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20071663 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:20071663 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20071663 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20071663 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20071663 | pubmed:articleTitle | Aberrant expression of the transcription factor Twist in adult T-cell leukemia. | lld:pubmed |
| pubmed-article:20071663 | pubmed:affiliation | Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan. | lld:pubmed |
| pubmed-article:20071663 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20071663 | pubmed:publicationType | Retracted Publication | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:20071663 | lld:pubmed |
