| pubmed-article:20057372 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20057372 | lifeskim:mentions | umls-concept:C0028754 | lld:lifeskim |
| pubmed-article:20057372 | lifeskim:mentions | umls-concept:C1521751 | lld:lifeskim |
| pubmed-article:20057372 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:20057372 | lifeskim:mentions | umls-concept:C0027307 | lld:lifeskim |
| pubmed-article:20057372 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:20057372 | lifeskim:mentions | umls-concept:C1417750 | lld:lifeskim |
| pubmed-article:20057372 | lifeskim:mentions | umls-concept:C0205266 | lld:lifeskim |
| pubmed-article:20057372 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:20057372 | pubmed:dateCreated | 2010-9-27 | lld:pubmed |
| pubmed-article:20057372 | pubmed:abstractText | The C57BL/6J (B6/J) male mouse represents a standard for diet-induced obesity (DIO) and is unique in expressing a loss-of-function nicotinamide nucleotide transhydrogenase (Nnt) gene. This mutation was associated with a marked reduction in glucose-stimulated insulin secretion from B6/J islets in vitro and moderately impaired glucose clearance in vivo. To assess the contribution of this Nnt mutation, we compared DIO responsiveness of Nnt-mutant B6/J males to Nnt wild-type C57BL/6NJ (B6/NJ) males over a 14-week period of feeding a high-fat (60% of calories) diet. Initial mean body weights at 6 weeks did not distinguish the substrains and both substrains were DIO-sensitive. However, B6/J males outgained the B6/NJ males, with a significant 3 g higher mean body weight at 20 weeks accompanied by significant increases in both lean and fat mass. Mean nonfasting serum glucose over time was also significantly higher in B6/J males, as was impairment of glucose tolerance assessed at 8 and 20 weeks of age. Serum leptin, but not insulin, was significantly higher in B6/J males over time. Potential contributions of the wild-type Nnt gene were demonstrable on a lower fat diet (10% of calories) where a significantly greater weight gain over time by B6/NJ males was correlated with a significantly higher serum insulin. In conclusion, DIO developed in response to 60% fat feeding regardless of Nnt allele status. Contribution of the B6/J-unique Nnt mutation was most evident in response to 10% fat feeding that resulted in reduced serum insulin and weight gain compared to B6/NJ males. | lld:pubmed |
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| pubmed-article:20057372 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20057372 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20057372 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20057372 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20057372 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20057372 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20057372 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20057372 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20057372 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20057372 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20057372 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20057372 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20057372 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20057372 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20057372 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20057372 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20057372 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20057372 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:20057372 | pubmed:issn | 1930-7381 | lld:pubmed |
| pubmed-article:20057372 | pubmed:author | pubmed-author:ZhangWeidongW | lld:pubmed |
| pubmed-article:20057372 | pubmed:author | pubmed-author:ReifsnyderPet... | lld:pubmed |
| pubmed-article:20057372 | pubmed:author | pubmed-author:LeiterEdward... | lld:pubmed |
| pubmed-article:20057372 | pubmed:author | pubmed-author:MacGregorGran... | lld:pubmed |
| pubmed-article:20057372 | pubmed:author | pubmed-author:NicholsonAnth... | lld:pubmed |
| pubmed-article:20057372 | pubmed:author | pubmed-author:MalcolmRachel... | lld:pubmed |
| pubmed-article:20057372 | pubmed:author | pubmed-author:LucasCharlott... | lld:pubmed |
| pubmed-article:20057372 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:20057372 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:20057372 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20057372 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20057372 | pubmed:pagination | 1902-5 | lld:pubmed |
| pubmed-article:20057372 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:20057372 | pubmed:meshHeading | pubmed-meshheading:20057372... | lld:pubmed |
| pubmed-article:20057372 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20057372 | pubmed:articleTitle | Diet-induced obesity in two C57BL/6 substrains with intact or mutant nicotinamide nucleotide transhydrogenase (Nnt) gene. | lld:pubmed |
| pubmed-article:20057372 | pubmed:affiliation | The Jackson Laboratory, Bar Harbor, Maine, USA. | lld:pubmed |
| pubmed-article:20057372 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20057372 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:20057372 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:20057372 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
