| pubmed-article:200559 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:200559 | lifeskim:mentions | umls-concept:C0206558 | lld:lifeskim |
| pubmed-article:200559 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:200559 | lifeskim:mentions | umls-concept:C0028631 | lld:lifeskim |
| pubmed-article:200559 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:200559 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:200559 | pubmed:dateCreated | 1978-1-27 | lld:pubmed |
| pubmed-article:200559 | pubmed:abstractText | Infection of human fibroblasts and HEp-2 cells with herpes simplex virus type 1 (HSV-1) produced a decrease in the intracellular levels of cyclic adenosine 5'- monophosphate (cAMP) and a concomitant increase in the cyclic guanosine 5'- monophosphate (cGMP) levels. In both cell cultures, changes in cyclic nucleotide levels were first observed at 6 h after viral inoculation and were maximal at 12 h. In human fibroblasts, the addition of theophylline, dibutyryl cAMP, or papaverine (cAMP-enhancing compounds) decreased significantly the yield of HSV-1, whereas the addition of insulin or dibutyryl cGMP (cGMP-enhancing compounds) increased the viral yield. In HEp-2 cells, only theophylline decreased the yield of HSV-1, and the cGMP-enhancing compounds had no apparent effect. Cyclic nucleotide enhancing compounds exhibited their effect only if added to either cell culture within the first 3 h after inoculation with HSV-1. | lld:pubmed |
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| pubmed-article:200559 | pubmed:language | eng | lld:pubmed |
| pubmed-article:200559 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:200559 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:200559 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:200559 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:200559 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:200559 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:200559 | pubmed:author | pubmed-author:NahmiasA JAJ | lld:pubmed |
| pubmed-article:200559 | pubmed:author | pubmed-author:AndersonR WRW | lld:pubmed |
| pubmed-article:200559 | pubmed:author | pubmed-author:StanwickT LTL | lld:pubmed |
| pubmed-article:200559 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:200559 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:200559 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:200559 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:200559 | pubmed:pagination | 342-7 | lld:pubmed |
| pubmed-article:200559 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:200559 | pubmed:meshHeading | pubmed-meshheading:200559-T... | lld:pubmed |
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| pubmed-article:200559 | pubmed:meshHeading | pubmed-meshheading:200559-D... | lld:pubmed |
| pubmed-article:200559 | pubmed:year | 1977 | lld:pubmed |
| pubmed-article:200559 | pubmed:articleTitle | Interaction between cyclic nucleotides and herpes simplex viruses: productive infection. | lld:pubmed |
| pubmed-article:200559 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:200559 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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