| pubmed-article:20051463 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20051463 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:20051463 | lifeskim:mentions | umls-concept:C0090388 | lld:lifeskim |
| pubmed-article:20051463 | lifeskim:mentions | umls-concept:C0164786 | lld:lifeskim |
| pubmed-article:20051463 | lifeskim:mentions | umls-concept:C0812228 | lld:lifeskim |
| pubmed-article:20051463 | lifeskim:mentions | umls-concept:C1421563 | lld:lifeskim |
| pubmed-article:20051463 | lifeskim:mentions | umls-concept:C1825025 | lld:lifeskim |
| pubmed-article:20051463 | lifeskim:mentions | umls-concept:C0205164 | lld:lifeskim |
| pubmed-article:20051463 | lifeskim:mentions | umls-concept:C2348867 | lld:lifeskim |
| pubmed-article:20051463 | lifeskim:mentions | umls-concept:C1998811 | lld:lifeskim |
| pubmed-article:20051463 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:20051463 | pubmed:dateCreated | 2010-4-5 | lld:pubmed |
| pubmed-article:20051463 | pubmed:abstractText | Insulin plays an essential role in metabolic homeostasis in mammals, and many of the underlying biochemical pathways are regulated via the canonical phosphatidylinositol 3-kinase/AKT pathway. To identify novel metabolic actions of insulin, we conducted a quantitative proteomics analysis of insulin-regulated 14-3-3-binding proteins in muscle cells. These studies revealed a novel role for insulin in the post-transcriptional regulation of mRNA expression. EDC3, a component of the mRNA decay and translation repression pathway associated with mRNA processing bodies, was shown to be phosphorylated by AKT downstream of insulin signaling. The major insulin-regulated site was mapped to Ser-161, and phosphorylation at this site led to increased 14-3-3 binding. Functional studies indicated that induction of 14-3-3 binding to EDC3 causes morphological changes in processing body structures, inhibition of microRNA-mediated mRNA post-transcriptional regulation, and alterations in the protein- protein interactions of EDC3. These data highlight an important new arm of the insulin signaling cascade in the regulation of mRNA utilization. | lld:pubmed |
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| pubmed-article:20051463 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20051463 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20051463 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20051463 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20051463 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20051463 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20051463 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:20051463 | pubmed:issn | 1535-9484 | lld:pubmed |
| pubmed-article:20051463 | pubmed:author | pubmed-author:JamesDavid... | lld:pubmed |
| pubmed-article:20051463 | pubmed:author | pubmed-author:GuilhausMicha... | lld:pubmed |
| pubmed-article:20051463 | pubmed:author | pubmed-author:HoehnKyle LKL | lld:pubmed |
| pubmed-article:20051463 | pubmed:author | pubmed-author:PreissThomasT | lld:pubmed |
| pubmed-article:20051463 | pubmed:author | pubmed-author:LaranceMarkM | lld:pubmed |
| pubmed-article:20051463 | pubmed:author | pubmed-author:HumphreysDavi... | lld:pubmed |
