Linked Life Data

20046712

Source:http://linkedlifedata.com/resource/pubmed/id/20046712

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SubjectPredicateObjectContext
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pubmed-article:20046712pubmed:issue2lld:pubmed
pubmed-article:20046712pubmed:dateCreated2010-1-4lld:pubmed
pubmed-article:20046712pubmed:abstractTextA simple reverse phase high-performance liquid chromatographic method has been developed for determining the concentration of metformin in rat plasma. The method employs C(18) column (300 mm x 2.4 mm i.d.), ammonium acetate (0.15 M) and acetonitrile (90:10; pH-5.5; 1.0 ml/min) as mobile phase and ultraviolet detection at 236 nm. Acetonitrile was used to simultaneously deproteinize rat plasma and extract metformin. The assay was linear in the concentration range of 0.33 mug-16.6 mug/ml with co-efficient of correlation 0.994. The retention time was 4.7 min. The method was found to be precise (% CV < 15%), accurate and suitable for pharmacokinetic study of orally administered metformin in rats.lld:pubmed
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pubmed-article:20046712pubmed:languageenglld:pubmed
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pubmed-article:20046712pubmed:statusPubMed-not-MEDLINElld:pubmed
pubmed-article:20046712pubmed:issn1998-3743lld:pubmed
pubmed-article:20046712pubmed:authorpubmed-author:ChopdeC TCTlld:pubmed
pubmed-article:20046712pubmed:authorpubmed-author:UmatheS NSNlld:pubmed
pubmed-article:20046712pubmed:authorpubmed-author:WanjariM MMMlld:pubmed
pubmed-article:20046712pubmed:authorpubmed-author:TajneM RMRlld:pubmed
pubmed-article:20046712pubmed:authorpubmed-author:ThereA WAWlld:pubmed
pubmed-article:20046712pubmed:issnTypeElectroniclld:pubmed
pubmed-article:20046712pubmed:volume70lld:pubmed
pubmed-article:20046712pubmed:ownerNLMlld:pubmed
pubmed-article:20046712pubmed:authorsCompleteYlld:pubmed
pubmed-article:20046712pubmed:pagination198-202lld:pubmed
pubmed-article:20046712pubmed:articleTitleRapid and Simple RPHPLC Method for the Estimation of Metformin in Rat Plasma.lld:pubmed
pubmed-article:20046712pubmed:affiliationDepartment of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Mahatma Jyotiba Fuley Shaikshanik Parisar, Amravati Road, Nagpur-440 033, India.lld:pubmed
pubmed-article:20046712pubmed:publicationTypeJournal Articlelld:pubmed