pubmed-article:20044005 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:20044005 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
pubmed-article:20044005 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
pubmed-article:20044005 | lifeskim:mentions | umls-concept:C1172779 | lld:lifeskim |
pubmed-article:20044005 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
pubmed-article:20044005 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
pubmed-article:20044005 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
pubmed-article:20044005 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
pubmed-article:20044005 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
pubmed-article:20044005 | lifeskim:mentions | umls-concept:C0439826 | lld:lifeskim |
pubmed-article:20044005 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
pubmed-article:20044005 | lifeskim:mentions | umls-concept:C0299477 | lld:lifeskim |
pubmed-article:20044005 | pubmed:issue | 5 | lld:pubmed |
pubmed-article:20044005 | pubmed:dateCreated | 2010-4-2 | lld:pubmed |
pubmed-article:20044005 | pubmed:abstractText | Bilateral olfactory bulbectomy (OBX) in rodents produces behavioral and neurochemical changes associated clinically with depression and schizophrenia. Most notably, OBX induces hyperlocomotion in response to the stress of exposure to a novel environment. We examined the role of the endocannabinoid system in regulating this locomotor response in OBX and sham-operated rats. In our study, OBX-induced hyperactivity was restricted to the first 3 min of the open field test, demonstrating the presence of novelty (0-3 min) and habituation (3-30 min) phases of the open field locomotor response. Levels of the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide were decreased in the ventral striatum, a brain region deafferented by OBX, whereas cannabinoid receptor densities were unaltered. In sham-operated rats, 2-AG levels in the ventral striatum were negatively correlated with distance traveled during the novelty phase. Thus, low levels of 2-AG are reflected in a hyperactive open field response. This correlation was not observed in OBX rats. Conversely, 2-AG levels in endocannabinoid-compromised OBX rats correlated with distance traveled during the habituation phase. In OBX rats, pharmacological blockade of cannabinoid CB(1) receptors with either AM251 (1 mg kg(-1) i.p.) or rimonabant (1 mg kg(-1) i.p.) increased distance traveled during the habituation phase. Thus, blockade of endocannabinoid signaling impairs habituation of the hyperlocomotor response in OBX, but not sham-operated, rats. By contrast, in sham-operated rats, effects of CB(1) antagonism were restricted to the novelty phase. These findings suggest that dysregulation in the endocannabinoid system, and 2-AG in particular, is implicated in the hyperactive locomotor response induced by OBX. Our studies suggest that drugs that enhance 2-AG signaling, such as 2-AG degradation inhibitors, might be useful in human brain disorders modeled by OBX. | lld:pubmed |
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pubmed-article:20044005 | pubmed:language | eng | lld:pubmed |
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pubmed-article:20044005 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:20044005 | pubmed:status | MEDLINE | lld:pubmed |