Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of beta-catenin signaling.
Source:http://linkedlifedata.com/resource/pubmed/id/20042609
J. Biol. Chem.
2010
Mar
19
285
12
8743-58
