Linked Life Data

20041972

Source:http://linkedlifedata.com/resource/pubmed/id/20041972

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pubmed-article:20041972pubmed:abstractTextIn view of the therapeutic potential of cardiomyocytes derived from induced pluripotent stem (iPS) cells (iPS-derived cardiomyocytes), in the present study we investigated in iPS-derived cardiomyocytes, the functional properties related to [Ca(2+) ](i) handling and contraction, the contribution of the sarcoplasmic reticulum (SR) Ca(2+) release to contraction and the b-adrenergic inotropic responsiveness. The two iPS clones investigated here were generated through infection of human foreskin fibroblasts (HFF) with retroviruses containing the four human genes: OCT4, Sox2, Klf4 and C-Myc. Our major findings showed that iPS-derived cardiomyocytes: (i) express cardiac specific RNA and proteins; (ii) exhibit negative force-frequency relations and mild (compared to adult) post-rest potentiation; (iii) respond to ryanodine and caffeine, albeit less than adult cardiomyocytes, and express the SR-Ca(2+) handling proteins ryanodine receptor and calsequestrin. Hence, this study demonstrates that in our cardiomyocytes clones differentiated from HFF-derived iPS, the functional properties related to excitation-contraction coupling, resemble in part those of adult cardiomyocytes.lld:pubmed
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pubmed-article:20041972pubmed:authorpubmed-author:BinahOferOlld:pubmed
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pubmed-article:20041972pubmed:copyrightInfo© 2011 The Author Journal of Cellular and Molecular Medicine © 2011 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd.lld:pubmed
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pubmed-article:20041972pubmed:articleTitleMolecular characterization and functional properties of cardiomyocytes derived from human inducible pluripotent stem cells.lld:pubmed
pubmed-article:20041972pubmed:affiliationThe Sohnis Family Stem Cells Center, Technion - Israel Institute of Technology, Haifa, Israel.lld:pubmed
pubmed-article:20041972pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20041972pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed