| pubmed-article:20033367 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20033367 | lifeskim:mentions | umls-concept:C0028754 | lld:lifeskim |
| pubmed-article:20033367 | lifeskim:mentions | umls-concept:C0034719 | lld:lifeskim |
| pubmed-article:20033367 | lifeskim:mentions | umls-concept:C1333572 | lld:lifeskim |
| pubmed-article:20033367 | lifeskim:mentions | umls-concept:C0118111 | lld:lifeskim |
| pubmed-article:20033367 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:20033367 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:20033367 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:20033367 | lifeskim:mentions | umls-concept:C1160266 | lld:lifeskim |
| pubmed-article:20033367 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:20033367 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:20033367 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:20033367 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:20033367 | pubmed:dateCreated | 2009-12-24 | lld:pubmed |
| pubmed-article:20033367 | pubmed:abstractText | It is well established that hyperinsulinemia, resulting from insulin resistance, plays a role in the pathophysiology of polycystic ovary syndrome (PCOS). The aim of this study was to investigate if ovarian follicular development and atresia are impaired in obese hyperinsulinemic (fa/fa) Zucker rats. To gain insight into the molecular mechanism of follicular atresia, we also examined the expression and localization of forkhead transcription factor FOXO1, a major regulator of cell fate decisions such as differentiation, cell-cycle arrest, and cell death. Serum insulin but not gonadotropin levels were significantly higher in obese (fa/fa) rats when compared to lean controls. Total ovarian follicle number and the percentage of atretic follicles were also significantly increased in obese (fa/fa) rats. Follicle atresia was associated with nuclear accumulation of FOXO1 transcription factor in TUNEL-positive granulosa cells. These results suggest a role for FOXO1 in granulosa cell apoptosis and increased ovarian follicle atresia associated with hyperinsulinemia. | lld:pubmed |
| pubmed-article:20033367 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20033367 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20033367 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20033367 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20033367 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20033367 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20033367 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20033367 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:20033367 | pubmed:issn | 1860-1499 | lld:pubmed |
| pubmed-article:20033367 | pubmed:author | pubmed-author:BrosensJan... | lld:pubmed |
| pubmed-article:20033367 | pubmed:author | pubmed-author:ItakuraAtsuoA | lld:pubmed |
| pubmed-article:20033367 | pubmed:author | pubmed-author:IshiharaOsamu... | lld:pubmed |
| pubmed-article:20033367 | pubmed:author | pubmed-author:KajiharaTakes... | lld:pubmed |
| pubmed-article:20033367 | pubmed:author | pubmed-author:SuzukiMotohar... | lld:pubmed |
| pubmed-article:20033367 | pubmed:author | pubmed-author:UchinoSatomiS | lld:pubmed |
| pubmed-article:20033367 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20033367 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:20033367 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20033367 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20033367 | pubmed:pagination | 216-21 | lld:pubmed |
| pubmed-article:20033367 | pubmed:meshHeading | pubmed-meshheading:20033367... | lld:pubmed |
| pubmed-article:20033367 | pubmed:meshHeading | pubmed-meshheading:20033367... | lld:pubmed |
| pubmed-article:20033367 | pubmed:meshHeading | pubmed-meshheading:20033367... | lld:pubmed |
| pubmed-article:20033367 | pubmed:meshHeading | pubmed-meshheading:20033367... | lld:pubmed |
| pubmed-article:20033367 | pubmed:meshHeading | pubmed-meshheading:20033367... | lld:pubmed |
| pubmed-article:20033367 | pubmed:meshHeading | pubmed-meshheading:20033367... | lld:pubmed |
| pubmed-article:20033367 | pubmed:meshHeading | pubmed-meshheading:20033367... | lld:pubmed |
| pubmed-article:20033367 | pubmed:meshHeading | pubmed-meshheading:20033367... | lld:pubmed |
| pubmed-article:20033367 | pubmed:meshHeading | pubmed-meshheading:20033367... | lld:pubmed |
| pubmed-article:20033367 | pubmed:meshHeading | pubmed-meshheading:20033367... | lld:pubmed |
| pubmed-article:20033367 | pubmed:meshHeading | pubmed-meshheading:20033367... | lld:pubmed |
| pubmed-article:20033367 | pubmed:meshHeading | pubmed-meshheading:20033367... | lld:pubmed |
| pubmed-article:20033367 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:20033367 | pubmed:articleTitle | Increased ovarian follicle atresia in obese Zucker rats is associated with enhanced expression of the forkhead transcription factor FOXO1. | lld:pubmed |
| pubmed-article:20033367 | pubmed:affiliation | Department of Obstetrics and Gynecology, Saitama Medical University, 38 Morohongo, Moroyama, Iruma-gun, Saitama 350-0495, Japan. kajihara@saitama-med.ac.jp | lld:pubmed |
| pubmed-article:20033367 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20033367 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:84482 | entrezgene:pubmed | pubmed-article:20033367 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20033367 | lld:entrezgene |
