Linked Life Data

20030932

Source:http://linkedlifedata.com/resource/pubmed/id/20030932

Statements in which the resource exists.
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pubmed-article:20030932pubmed:abstractTextTo investigate the methylation status of CpG islands of the secreted frizzled-related protein (SFRP) gene promoter region in malignant hematopoietic cell lines, and to explore the possible relationship of CpG abnormal methylation status with pathogenic mechanism of hematologic malignancies. Methylation-specific PCR was used to detect the status of SFRP gene promoter region in nine malignant hematopoietic cell lines and peripheral blood mononuclear cells from healthy people. The results indicated that hypermethylation of 2 genes coding for SFRP1 and 2 were present in nine malignant hematopoietic cell lines, however, methylation and unmethylation of SFRP4 were both detected in CA46, HL60 and U937 cell lines, and SFRP5 in U266 as well. None of the normal mononuclear cells showed methylation of SFRP 1-5 genes. It is concluded that the hypermethylation of SFRP genes is related to the evolution of malignant hematopoiesis. Methylation of SFRP genes may serve as potential independent biomarkers for early detection of hematologic malignancies.lld:pubmed
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pubmed-article:20030932pubmed:articleTitle[Methylation status of CpG islands in secreted frizzled-related protein gene promoter region of malignant hematopoietic cell lines].lld:pubmed
pubmed-article:20030932pubmed:affiliationDepartment of Hematology, Union Hospital, Fujian Medical University; Fujian Institute of Hematology, Fuzhou 350001, Fujian Province, China.lld:pubmed
pubmed-article:20030932pubmed:publicationTypeJournal Articlelld:pubmed
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