pubmed-article:20028004 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:20028004 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
pubmed-article:20028004 | lifeskim:mentions | umls-concept:C0011923 | lld:lifeskim |
pubmed-article:20028004 | lifeskim:mentions | umls-concept:C0031268 | lld:lifeskim |
pubmed-article:20028004 | lifeskim:mentions | umls-concept:C0006118 | lld:lifeskim |
pubmed-article:20028004 | lifeskim:mentions | umls-concept:C0001128 | lld:lifeskim |
pubmed-article:20028004 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
pubmed-article:20028004 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
pubmed-article:20028004 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
pubmed-article:20028004 | lifeskim:mentions | umls-concept:C0032743 | lld:lifeskim |
pubmed-article:20028004 | lifeskim:mentions | umls-concept:C0060058 | lld:lifeskim |
pubmed-article:20028004 | lifeskim:mentions | umls-concept:C2347885 | lld:lifeskim |
pubmed-article:20028004 | lifeskim:mentions | umls-concept:C0072186 | lld:lifeskim |
pubmed-article:20028004 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
pubmed-article:20028004 | lifeskim:mentions | umls-concept:C0599278 | lld:lifeskim |
pubmed-article:20028004 | pubmed:issue | 2 | lld:pubmed |
pubmed-article:20028004 | pubmed:dateCreated | 2010-1-21 | lld:pubmed |
pubmed-article:20028004 | pubmed:abstractText | The non-natural amino acids (R)- and (S)-2-amino-3-fluoro-2-methylpropanoic acid 5 and (R)- and (S)-3-fluoro-2-methyl-2-N-(methylamino)propanoic acid 8 were synthesized in shorter reaction sequences than in the original report starting from enantiomerically pure (S)- and (R)-alpha-methyl-serine, respectively. The reaction sequence provided the cyclic sulfamidate precursors for radiosynthesis of (R)- and (S)-[(18)F]5 and (R)- and (S)-[(18)F]8 in fewer steps than in the original report. (R)- and (S)-[(18)F]5 and(R)- and (S)-[(18)F]8 were synthesized by no-carrier-added nucleophilic [(18)F]fluorination in 52-66% decay-corrected yields with radiochemical purity over 99%. The cell assays showed that all four compounds were substrates for amino acid transport and enter 9L rat gliosarcoma cells in vitro at least in part by system A amino acid transport. The biodistribution studies demonstrated that in vivo tumor to normal brain ratios for all compounds were high with ratios of 20:1 to115:1 in rats with intracranial 9L tumors. The (R)-enantiomers of [(18)F]5 and [(18)F]8 demonstrated higher tumor uptake in vivo compared to the (S)-enantiomers. | lld:pubmed |
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pubmed-article:20028004 | pubmed:language | eng | lld:pubmed |
pubmed-article:20028004 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20028004 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:20028004 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:20028004 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20028004 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:20028004 | pubmed:month | Jan | lld:pubmed |
pubmed-article:20028004 | pubmed:issn | 1520-4804 | lld:pubmed |
pubmed-article:20028004 | pubmed:author | pubmed-author:OlsonJeffrey... | lld:pubmed |
pubmed-article:20028004 | pubmed:author | pubmed-author:YuWeipingW | lld:pubmed |
pubmed-article:20028004 | pubmed:author | pubmed-author:GoodmanMark... | lld:pubmed |
pubmed-article:20028004 | pubmed:author | pubmed-author:McConathyJona... | lld:pubmed |
pubmed-article:20028004 | pubmed:author | pubmed-author:MalveauxEugen... | lld:pubmed |
pubmed-article:20028004 | pubmed:author | pubmed-author:CampVernon... | lld:pubmed |
pubmed-article:20028004 | pubmed:author | pubmed-author:ZhangZhaobinZ | lld:pubmed |
pubmed-article:20028004 | pubmed:author | pubmed-author:WilliamsLarry... | lld:pubmed |
pubmed-article:20028004 | pubmed:issnType | Electronic | lld:pubmed |
pubmed-article:20028004 | pubmed:day | 28 | lld:pubmed |
pubmed-article:20028004 | pubmed:volume | 53 | lld:pubmed |
pubmed-article:20028004 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:20028004 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:20028004 | pubmed:pagination | 876-86 | lld:pubmed |
pubmed-article:20028004 | pubmed:dateRevised | 2011-7-20 | lld:pubmed |
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pubmed-article:20028004 | pubmed:year | 2010 | lld:pubmed |
pubmed-article:20028004 | pubmed:articleTitle | Synthesis, radiolabeling, and biological evaluation of (R)- and (S)-2-amino-3-[(18)F]fluoro-2-methylpropanoic acid (FAMP) and (R)- and (S)-3-[(18)F]fluoro-2-methyl-2-N-(methylamino)propanoic acid (NMeFAMP) as potential PET radioligands for imaging brain tumors. | lld:pubmed |
pubmed-article:20028004 | pubmed:affiliation | Department of Radiology, School of Medicine, Emory University, 1364 Clifton Road NE, Atlanta, Georgia 30322, USA. | lld:pubmed |
pubmed-article:20028004 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:20028004 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:20028004 | lld:chembl |