Linked Life Data

20023636

Source:http://linkedlifedata.com/resource/pubmed/id/20023636

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:20023636rdf:typepubmed:Citationlld:pubmed
pubmed-article:20023636lifeskim:mentionsumls-concept:C0020094lld:lifeskim
pubmed-article:20023636lifeskim:mentionsumls-concept:C0205466lld:lifeskim
pubmed-article:20023636lifeskim:mentionsumls-concept:C0521119lld:lifeskim
pubmed-article:20023636lifeskim:mentionsumls-concept:C0039062lld:lifeskim
pubmed-article:20023636lifeskim:mentionsumls-concept:C1521797lld:lifeskim
pubmed-article:20023636lifeskim:mentionsumls-concept:C0282629lld:lifeskim
pubmed-article:20023636lifeskim:mentionsumls-concept:C0086597lld:lifeskim
pubmed-article:20023636pubmed:issue1lld:pubmed
pubmed-article:20023636pubmed:dateCreated2010-1-8lld:pubmed
pubmed-article:20023636pubmed:abstractTextHuman T cell leukemia virus type 1 (HTLV-1) is a lymphotropic retrovirus whose cell-to-cell transmission requires cell contacts. HTLV-1-infected T lymphocytes form 'virological synapses', but the mechanism of HTLV-1 transmission remains poorly understood. We show here that HTLV-1-infected T lymphocytes transiently store viral particles as carbohydrate-rich extracellular assemblies that are held together and attached to the cell surface by virally-induced extracellular matrix components, including collagen and agrin, and cellular linker proteins, such as tetherin and galectin-3. Extracellular viral assemblies rapidly adhere to other cells upon cell contact, allowing virus spread and infection of target cells. Their removal strongly reduces the ability of HTLV-1-producing cells to infect target cells. Our findings unveil a novel virus transmission mechanism based on the generation of extracellular viral particle assemblies whose structure, composition and function resemble those of bacterial biofilms. HTLV-1 biofilm-like structures represent a major route for virus transmission from cell to cell.lld:pubmed
pubmed-article:20023636pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20023636pubmed:languageenglld:pubmed
pubmed-article:20023636pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20023636pubmed:citationSubsetIMlld:pubmed
pubmed-article:20023636pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20023636pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20023636pubmed:statusMEDLINElld:pubmed
pubmed-article:20023636pubmed:monthJanlld:pubmed
pubmed-article:20023636pubmed:issn1546-170Xlld:pubmed
pubmed-article:20023636pubmed:authorpubmed-author:GessainAntoin...lld:pubmed
pubmed-article:20023636pubmed:authorpubmed-author:AlcoverAndrés...lld:pubmed
pubmed-article:20023636pubmed:authorpubmed-author:GoutOlivierOlld:pubmed
pubmed-article:20023636pubmed:authorpubmed-author:SachseMartinMlld:pubmed
pubmed-article:20023636pubmed:authorpubmed-author:LasserreRémiRlld:pubmed
pubmed-article:20023636pubmed:authorpubmed-author:ThoulouzeMari...lld:pubmed
pubmed-article:20023636pubmed:authorpubmed-author:GuadagniniSté...lld:pubmed
pubmed-article:20023636pubmed:authorpubmed-author:Pais-CorreiaA...lld:pubmed
pubmed-article:20023636pubmed:authorpubmed-author:RobbiatiValen...lld:pubmed
pubmed-article:20023636pubmed:issnTypeElectroniclld:pubmed
pubmed-article:20023636pubmed:volume16lld:pubmed
pubmed-article:20023636pubmed:ownerNLMlld:pubmed
pubmed-article:20023636pubmed:authorsCompleteYlld:pubmed
pubmed-article:20023636pubmed:pagination83-9lld:pubmed
pubmed-article:20023636pubmed:meshHeadingpubmed-meshheading:20023636...lld:pubmed
pubmed-article:20023636pubmed:meshHeadingpubmed-meshheading:20023636...lld:pubmed
pubmed-article:20023636pubmed:meshHeadingpubmed-meshheading:20023636...lld:pubmed
pubmed-article:20023636pubmed:meshHeadingpubmed-meshheading:20023636...lld:pubmed
pubmed-article:20023636pubmed:meshHeadingpubmed-meshheading:20023636...lld:pubmed
pubmed-article:20023636pubmed:meshHeadingpubmed-meshheading:20023636...lld:pubmed
pubmed-article:20023636pubmed:meshHeadingpubmed-meshheading:20023636...lld:pubmed
pubmed-article:20023636pubmed:meshHeadingpubmed-meshheading:20023636...lld:pubmed
pubmed-article:20023636pubmed:meshHeadingpubmed-meshheading:20023636...lld:pubmed
pubmed-article:20023636pubmed:meshHeadingpubmed-meshheading:20023636...lld:pubmed
pubmed-article:20023636pubmed:meshHeadingpubmed-meshheading:20023636...lld:pubmed
pubmed-article:20023636pubmed:meshHeadingpubmed-meshheading:20023636...lld:pubmed
pubmed-article:20023636pubmed:year2010lld:pubmed
pubmed-article:20023636pubmed:articleTitleBiofilm-like extracellular viral assemblies mediate HTLV-1 cell-to-cell transmission at virological synapses.lld:pubmed
pubmed-article:20023636pubmed:affiliationInstitut Pasteur, Unité de Biologie Cellulaire des Lymphocytes, Centre National de Recherche Scientifique (CNRS), Unité de Recherche Associée 1961, Paris, France.lld:pubmed
pubmed-article:20023636pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20023636pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:20023636lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:20023636lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:20023636lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:20023636lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:20023636lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:20023636lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:20023636lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:20023636lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:20023636lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:20023636lld:pubmed