| pubmed-article:20017190 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20017190 | lifeskim:mentions | umls-concept:C0019629 | lld:lifeskim |
| pubmed-article:20017190 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:20017190 | lifeskim:mentions | umls-concept:C0664943 | lld:lifeskim |
| pubmed-article:20017190 | lifeskim:mentions | umls-concept:C0868955 | lld:lifeskim |
| pubmed-article:20017190 | lifeskim:mentions | umls-concept:C0678640 | lld:lifeskim |
| pubmed-article:20017190 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:20017190 | pubmed:dateCreated | 2010-1-4 | lld:pubmed |
| pubmed-article:20017190 | pubmed:abstractText | The endoplasmic reticulum (ER) protein tapasin is essential for the loading of high-affinity peptides onto MHC class I molecules. It mediates peptide editing, i.e. the binding of peptides of successively higher affinity until class I molecules pass ER quality control and exit to the cell surface. The molecular mechanism of action of tapasin is unknown. We describe here the reconstitution of tapasin-mediated peptide editing on class I molecules in the lumen of microsomal membranes. We find that in a competitive situation between high- and low-affinity peptides, tapasin mediates the binding of the high-affinity peptide to class I by accelerating the dissociation of the peptide from an unstable intermediate of the binding reaction. | lld:pubmed |
| pubmed-article:20017190 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20017190 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20017190 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20017190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20017190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20017190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20017190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20017190 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20017190 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:20017190 | pubmed:issn | 1521-4141 | lld:pubmed |
| pubmed-article:20017190 | pubmed:author | pubmed-author:KalbacherHube... | lld:pubmed |
| pubmed-article:20017190 | pubmed:author | pubmed-author:PraveenP V... | lld:pubmed |
| pubmed-article:20017190 | pubmed:author | pubmed-author:SpringerSebas... | lld:pubmed |
| pubmed-article:20017190 | pubmed:author | pubmed-author:YanevaRakinaR | lld:pubmed |
| pubmed-article:20017190 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20017190 | pubmed:volume | 40 | lld:pubmed |
| pubmed-article:20017190 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20017190 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20017190 | pubmed:pagination | 214-24 | lld:pubmed |
| pubmed-article:20017190 | pubmed:meshHeading | pubmed-meshheading:20017190... | lld:pubmed |
| pubmed-article:20017190 | pubmed:meshHeading | pubmed-meshheading:20017190... | lld:pubmed |
| pubmed-article:20017190 | pubmed:meshHeading | pubmed-meshheading:20017190... | lld:pubmed |
| pubmed-article:20017190 | pubmed:meshHeading | pubmed-meshheading:20017190... | lld:pubmed |
| pubmed-article:20017190 | pubmed:meshHeading | pubmed-meshheading:20017190... | lld:pubmed |
| pubmed-article:20017190 | pubmed:meshHeading | pubmed-meshheading:20017190... | lld:pubmed |
| pubmed-article:20017190 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20017190 | pubmed:articleTitle | Tapasin edits peptides on MHC class I molecules by accelerating peptide exchange. | lld:pubmed |
| pubmed-article:20017190 | pubmed:affiliation | Biochemistry and Cell Biology, Jacobs University Bremen, Bremen, Germany. | lld:pubmed |
| pubmed-article:20017190 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20017190 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:6892 | entrezgene:pubmed | pubmed-article:20017190 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20017190 | lld:entrezgene |
