| pubmed-article:20008302 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20008302 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:20008302 | lifeskim:mentions | umls-concept:C0026764 | lld:lifeskim |
| pubmed-article:20008302 | lifeskim:mentions | umls-concept:C0039736 | lld:lifeskim |
| pubmed-article:20008302 | lifeskim:mentions | umls-concept:C0011777 | lld:lifeskim |
| pubmed-article:20008302 | lifeskim:mentions | umls-concept:C1144149 | lld:lifeskim |
| pubmed-article:20008302 | lifeskim:mentions | umls-concept:C0683941 | lld:lifeskim |
| pubmed-article:20008302 | lifeskim:mentions | umls-concept:C1518321 | lld:lifeskim |
| pubmed-article:20008302 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:20008302 | pubmed:dateCreated | 2010-2-19 | lld:pubmed |
| pubmed-article:20008302 | pubmed:abstractText | The objective of this case-control study was to compare the efficacy and toxicity of lenalidomide plus dexamethasone (len/dex) versus thalidomide plus dexamethasone (thal/dex) as initial therapy for newly diagnosed myeloma. We retrospectively studied 411 newly diagnosed patients treated with len/dex (228) or thal/dex (183) at the Mayo Clinic. The differences were similar in a matched-pair analysis that adjusted for age, sex, transplantation status, and dexamethasone dose. The proportions of patients achieving at least a partial response to len/dex and thal/dex were 80.3% versus 61.2%, respectively (P < .001); very good partial response rates were 34.2% and 12.0%, respectively (P < .001). Patients receiving len/dex had longer time to progression (median, 27.4 vs 17.2 months; P = .019), progression-free survival (median, 26.7 vs 17.1 months; P = .036), and overall survival (median not reached vs 57.2 months; P = .018). A similar proportion of patients in the 2 groups experienced at least one grade 3 or 4 adverse event (57.5% vs 54.6%, P = .568). Main grade 3 or 4 toxicities of len/dex were hematologic, mainly neutropenia (14.6% vs 0.6%, P < .001); the most common toxicities in thal/dex were venous thromboembolism (15.3% vs 9.2%, P = .058) and peripheral neuropathy (10.4% vs 0.9%, P < .001). Len/dex appears well-tolerated and more effective than thal/dex. Randomized trials are needed to confirm these results. | lld:pubmed |
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| pubmed-article:20008302 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20008302 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20008302 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:20008302 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20008302 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20008302 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20008302 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20008302 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20008302 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:20008302 | pubmed:issn | 1528-0020 | lld:pubmed |
| pubmed-article:20008302 | pubmed:author | pubmed-author:WitzigThomas... | lld:pubmed |
| pubmed-article:20008302 | pubmed:author | pubmed-author:DispenzieriAn... | lld:pubmed |
| pubmed-article:20008302 | pubmed:author | pubmed-author:GertzMorie... | lld:pubmed |
| pubmed-article:20008302 | pubmed:author | pubmed-author:LacyMartha... | lld:pubmed |
| pubmed-article:20008302 | pubmed:author | pubmed-author:KyleRobert... | lld:pubmed |
| pubmed-article:20008302 | pubmed:author | pubmed-author:GreippPhilip... | lld:pubmed |
| pubmed-article:20008302 | pubmed:author | pubmed-author:RajkumarS... | lld:pubmed |
| pubmed-article:20008302 | pubmed:author | pubmed-author:LustJohn AJA | lld:pubmed |
| pubmed-article:20008302 | pubmed:author | pubmed-author:FonsecaRafael... | lld:pubmed |
| pubmed-article:20008302 | pubmed:author | pubmed-author:KumarShajiS | lld:pubmed |
| pubmed-article:20008302 | pubmed:author | pubmed-author:RussellStephe... | lld:pubmed |
| pubmed-article:20008302 | pubmed:author | pubmed-author:BergsagelP... | lld:pubmed |
| pubmed-article:20008302 | pubmed:author | pubmed-author:StewartA... | lld:pubmed |
| pubmed-article:20008302 | pubmed:author | pubmed-author:RoyVivekV | lld:pubmed |
| pubmed-article:20008302 | pubmed:author | pubmed-author:ReederCraig... | lld:pubmed |
| pubmed-article:20008302 | pubmed:author | pubmed-author:ZeldenrustSte... | lld:pubmed |
| pubmed-article:20008302 | pubmed:author | pubmed-author:DingliDavidD | lld:pubmed |
| pubmed-article:20008302 | pubmed:author | pubmed-author:HaymanSuzanne... | lld:pubmed |
| pubmed-article:20008302 | pubmed:author | pubmed-author:BuadiFrancisF | lld:pubmed |
| pubmed-article:20008302 | pubmed:author | pubmed-author:GayFrancescaF | lld:pubmed |
| pubmed-article:20008302 | pubmed:author | pubmed-author:MikhaelJoseph... | lld:pubmed |
| pubmed-article:20008302 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20008302 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:20008302 | pubmed:volume | 115 | lld:pubmed |
| pubmed-article:20008302 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20008302 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20008302 | pubmed:pagination | 1343-50 | lld:pubmed |
| pubmed-article:20008302 | pubmed:dateRevised | 2011-7-25 | lld:pubmed |
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| pubmed-article:20008302 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20008302 | pubmed:articleTitle | Lenalidomide plus dexamethasone versus thalidomide plus dexamethasone in newly diagnosed multiple myeloma: a comparative analysis of 411 patients. | lld:pubmed |
| pubmed-article:20008302 | pubmed:affiliation | Department of Internal Medicine, Division of Hematology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. | lld:pubmed |
| pubmed-article:20008302 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20008302 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:20008302 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:20008302 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
