| pubmed-article:20006667 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20006667 | lifeskim:mentions | umls-concept:C0376387 | lld:lifeskim |
| pubmed-article:20006667 | lifeskim:mentions | umls-concept:C0023911 | lld:lifeskim |
| pubmed-article:20006667 | lifeskim:mentions | umls-concept:C0021080 | lld:lifeskim |
| pubmed-article:20006667 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:20006667 | lifeskim:mentions | umls-concept:C0021079 | lld:lifeskim |
| pubmed-article:20006667 | lifeskim:mentions | umls-concept:C0175630 | lld:lifeskim |
| pubmed-article:20006667 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:20006667 | pubmed:dateCreated | 2010-3-1 | lld:pubmed |
| pubmed-article:20006667 | pubmed:abstractText | Human leukocyte antigen (HLA)-specific antibodies (Abs) were examined in 73 clinically stable liver transplant recipients divided into group A (n = 19; clinically tolerant), group B (n = 34; undergoing weaning, on minimal immunosuppression), and group C (n = 20; had failed drug withdrawal or weaning never attempted). Of 19 patients in group A, six (32%) had anti-HLA Abs; none were donor-specific. In contrast, 23 of 34 patients (67%) in group B and nine of 20 patients (45%) in group C exhibited anti-HLA Abs (p = 0.02). Furthermore, 15 of 19 patients in groups B and C (9/12, p = 0.01 and 6/7, p = 0.01, respectively) exhibited donor-specific anti-HLA Abs. The prevalence of donor-specific HLA Abs was significantly higher in nontolerant patients. Five years after initial evaluation, >90% (18/19) group A patients remained off immunosuppression. One of seven of these patients available for retesting exhibited donor-specific Abs. In group B, two-fourths of 34 patients (12%) weaned successfully were HLA-Ab negative; four patients who experienced rejection while undergoing weaning exhibited anti-HLA Ab initially and at 5 years. Thus, most of the liver recipients off immunosuppression lacked donor-specific alloAbs. The occurrence of these alloAbs should now be examined prospectively in a drug weaning trial. | lld:pubmed |
| pubmed-article:20006667 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20006667 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20006667 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20006667 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20006667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20006667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20006667 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20006667 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:20006667 | pubmed:issn | 1879-1166 | lld:pubmed |
| pubmed-article:20006667 | pubmed:author | pubmed-author:ThomsonAngus... | lld:pubmed |
| pubmed-article:20006667 | pubmed:author | pubmed-author:ReyesJorgeJ | lld:pubmed |
| pubmed-article:20006667 | pubmed:author | pubmed-author:MazariegosGeo... | lld:pubmed |
| pubmed-article:20006667 | pubmed:author | pubmed-author:ZeeviAdrianaA | lld:pubmed |
| pubmed-article:20006667 | pubmed:author | pubmed-author:BentlejewskiC... | lld:pubmed |
| pubmed-article:20006667 | pubmed:author | pubmed-author:CastellanetaA... | lld:pubmed |
| pubmed-article:20006667 | pubmed:author | pubmed-author:GirnitaAlinA | lld:pubmed |
| pubmed-article:20006667 | pubmed:copyrightInfo | (c) 2010 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:20006667 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20006667 | pubmed:volume | 71 | lld:pubmed |
| pubmed-article:20006667 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20006667 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20006667 | pubmed:pagination | 274-6 | lld:pubmed |
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| pubmed-article:20006667 | pubmed:meshHeading | pubmed-meshheading:20006667... | lld:pubmed |
| pubmed-article:20006667 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20006667 | pubmed:articleTitle | Liver transplant recipients weaned off immunosuppression lack circulating donor-specific antibodies. | lld:pubmed |
| pubmed-article:20006667 | pubmed:affiliation | Thomas E. Starzl Transplantation Institute and Department of Pathology, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, Pennsylvania, USA. | lld:pubmed |
| pubmed-article:20006667 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20006667 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:20006667 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
