| pubmed-article:20006497 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20006497 | lifeskim:mentions | umls-concept:C0034255 | lld:lifeskim |
| pubmed-article:20006497 | lifeskim:mentions | umls-concept:C0164786 | lld:lifeskim |
| pubmed-article:20006497 | lifeskim:mentions | umls-concept:C0034251 | lld:lifeskim |
| pubmed-article:20006497 | lifeskim:mentions | umls-concept:C0812228 | lld:lifeskim |
| pubmed-article:20006497 | lifeskim:mentions | umls-concept:C1335631 | lld:lifeskim |
| pubmed-article:20006497 | lifeskim:mentions | umls-concept:C0444669 | lld:lifeskim |
| pubmed-article:20006497 | lifeskim:mentions | umls-concept:C1706204 | lld:lifeskim |
| pubmed-article:20006497 | lifeskim:mentions | umls-concept:C1555721 | lld:lifeskim |
| pubmed-article:20006497 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:20006497 | pubmed:dateCreated | 2010-2-3 | lld:pubmed |
| pubmed-article:20006497 | pubmed:abstractText | 2,3,5-Trisubstituted pyridines have been designed as potent AKT inhibitors that are selective against ROCK1 based on the comparison between AKT and ROCK1 structures. Substitution at the 2-position of the core pyridine is the key element to provide selectivity against ROCK1. An X-ray co-crystal structure of 9p in PKA supports the proposed rationale of ROCK1 selectivity. | lld:pubmed |
| pubmed-article:20006497 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20006497 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20006497 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20006497 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20006497 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20006497 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20006497 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20006497 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20006497 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20006497 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:20006497 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:20006497 | pubmed:author | pubmed-author:WoodEdgar RER | lld:pubmed |
| pubmed-article:20006497 | pubmed:author | pubmed-author:LinHongH | lld:pubmed |
| pubmed-article:20006497 | pubmed:author | pubmed-author:MinthornElisa... | lld:pubmed |
| pubmed-article:20006497 | pubmed:author | pubmed-author:ElkinsPatrici... | lld:pubmed |
| pubmed-article:20006497 | pubmed:author | pubmed-author:HeerdingDirk... | lld:pubmed |
| pubmed-article:20006497 | pubmed:author | pubmed-author:ZengJinJ | lld:pubmed |
| pubmed-article:20006497 | pubmed:author | pubmed-author:LuengoJuan... | lld:pubmed |
| pubmed-article:20006497 | pubmed:author | pubmed-author:ConchaNestor... | lld:pubmed |
| pubmed-article:20006497 | pubmed:author | pubmed-author:LaiZhihongZ | lld:pubmed |
| pubmed-article:20006497 | pubmed:author | pubmed-author:KnickVictoria... | lld:pubmed |
| pubmed-article:20006497 | pubmed:author | pubmed-author:ChoudhryAntho... | lld:pubmed |
| pubmed-article:20006497 | pubmed:author | pubmed-author:WangWenyongW | lld:pubmed |
| pubmed-article:20006497 | pubmed:author | pubmed-author:YamashitaDenn... | lld:pubmed |
| pubmed-article:20006497 | pubmed:author | pubmed-author:RhodesNelsonN | lld:pubmed |
| pubmed-article:20006497 | pubmed:author | pubmed-author:XieRenR | lld:pubmed |
| pubmed-article:20006497 | pubmed:author | pubmed-author:StrumSusan... | lld:pubmed |
| pubmed-article:20006497 | pubmed:author | pubmed-author:NidarmarthySi... | lld:pubmed |
| pubmed-article:20006497 | pubmed:copyrightInfo | Copyright 2009 Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:20006497 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20006497 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:20006497 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:20006497 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20006497 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20006497 | pubmed:pagination | 673-8 | lld:pubmed |
| pubmed-article:20006497 | pubmed:meshHeading | pubmed-meshheading:20006497... | lld:pubmed |
| pubmed-article:20006497 | pubmed:meshHeading | pubmed-meshheading:20006497... | lld:pubmed |
| pubmed-article:20006497 | pubmed:meshHeading | pubmed-meshheading:20006497... | lld:pubmed |
| pubmed-article:20006497 | pubmed:meshHeading | pubmed-meshheading:20006497... | lld:pubmed |
| pubmed-article:20006497 | pubmed:meshHeading | pubmed-meshheading:20006497... | lld:pubmed |
| pubmed-article:20006497 | pubmed:meshHeading | pubmed-meshheading:20006497... | lld:pubmed |
| pubmed-article:20006497 | pubmed:meshHeading | pubmed-meshheading:20006497... | lld:pubmed |
| pubmed-article:20006497 | pubmed:meshHeading | pubmed-meshheading:20006497... | lld:pubmed |
| pubmed-article:20006497 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20006497 | pubmed:articleTitle | 2,3,5-Trisubstituted pyridines as selective AKT inhibitors-Part I: Substitution at 2-position of the core pyridine for ROCK1 selectivity. | lld:pubmed |
| pubmed-article:20006497 | pubmed:affiliation | Oncology Medicinal Chemistry, GlaxoSmithKline, 1250 S. Collegeville, Rd., Collegeville, PA 19426, United States. hong.2.lin@gsk.com | lld:pubmed |
| pubmed-article:20006497 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:20006497 | lld:chembl |
