| pubmed-article:199733 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:199733 | lifeskim:mentions | umls-concept:C0038975 | lld:lifeskim |
| pubmed-article:199733 | lifeskim:mentions | umls-concept:C0008546 | lld:lifeskim |
| pubmed-article:199733 | lifeskim:mentions | umls-concept:C0003343 | lld:lifeskim |
| pubmed-article:199733 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:199733 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:199733 | pubmed:dateCreated | 1977-12-29 | lld:pubmed |
| pubmed-article:199733 | pubmed:abstractText | We have studied the binding of the tumor antigen (T-antigen) of simian virus 40 to simian virus 40 chromatin (minichromosomes). The minichromosomes isolated from infected cells by a modification of standard techniques were relatively free of contaminating RNA and cellular DNA and had a ratio (by weight) of protein to DNA of approximately 1; their DNA was 50 to 60% digestible to an acid-soluble form by staphylococcal nuclease. Cleavage of this chromatin with restriction endonucleases indicated that the nuclease-resistant regions were randomly distributed in the population of minichromosomes, but were not randomly distributed within minichromosomes. Only 20 to 35% of these minichromosomes adsorbed nonspecifically to nitrocellulose filters, permitting binding studies between simian virus 40 T-antigen and chromatin to be performed. Approximately two to three times as much T-antigen was required to bind chromatin as to bind an equivalent amount of free DNA. When T-antigen was present in excess, both chromatin and free DNA were quantitatively retained on the filters. On the other hand, when DNA or chromatin was present in excess, only one-third as much chromatin as DNA was retained. We suggest that T-antigen-chromatin complexes may be formed by the cooperative binding of T-antigen to chromatin, whereas T-antigen-DNA complexes may be formed by simple bimolecular interactions. | lld:pubmed |
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| pubmed-article:199733 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:199733 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:199733 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:199733 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:199733 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:199733 | pubmed:author | pubmed-author:LivingstonD... | lld:pubmed |
| pubmed-article:199733 | pubmed:author | pubmed-author:MartinR GRG | lld:pubmed |
| pubmed-article:199733 | pubmed:author | pubmed-author:Persico-DiLau... | lld:pubmed |
| pubmed-article:199733 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:199733 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:199733 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:199733 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:199733 | pubmed:pagination | 451-60 | lld:pubmed |
| pubmed-article:199733 | pubmed:dateRevised | 2010-9-2 | lld:pubmed |
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| pubmed-article:199733 | pubmed:meshHeading | pubmed-meshheading:199733-D... | lld:pubmed |
| pubmed-article:199733 | pubmed:year | 1977 | lld:pubmed |
| pubmed-article:199733 | pubmed:articleTitle | Interaction of Simian Virus 40 chromatin with Simian Virus 40 T-antigen. | lld:pubmed |
| pubmed-article:199733 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:199733 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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