| pubmed-article:1995899 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1995899 | lifeskim:mentions | umls-concept:C0443286 | lld:lifeskim |
| pubmed-article:1995899 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:1995899 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:1995899 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:1995899 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:1995899 | lifeskim:mentions | umls-concept:C1706204 | lld:lifeskim |
| pubmed-article:1995899 | lifeskim:mentions | umls-concept:C1555721 | lld:lifeskim |
| pubmed-article:1995899 | lifeskim:mentions | umls-concept:C0772162 | lld:lifeskim |
| pubmed-article:1995899 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1995899 | pubmed:dateCreated | 1991-3-27 | lld:pubmed |
| pubmed-article:1995899 | pubmed:abstractText | The first example of a no-carrier-added 18F-labeled catecholamine, 6-[18F]fluoronorepinephrine (6-[18F]FNE), has been synthesized via nucleophilic aromatic substitution. The racemic mixture was resolved on a chiral HPLC column to obtain pure samples of (-)-6-[18F]FNE and (+)6-[18F]FNE. Radiochemical yields of 20% at the end of bombardment (EOB) for the racemic mixture (synthesis time 93 min), 6% for each enantiomer (synthesis time 128 min) with a specific activity of 2-5 Ci/mumol at EOB were obtained. Chiral HPLC peak assignment for the resolved enantiomers was achieved by using two independent methods: polarimetric determination and reaction with dopamine beta-hydroxylase. Positron emission tomography (PET) studies with racemic 6-[18F]FNE show high uptake and retention in the baboon heart. This work demonstrates that nucleophilic aromatic substitution by [18F]fluoride ion is applicable to systems having electron-rich aromatic rings, leading to high specific activity radiopharmaceuticals. Furthermore, the suitably protected dihydroxynitrobenzaldehyde 1 may serve as a useful synthetic precursor for the radiosynthesis of other complex 18F-labeled radiotracers. | lld:pubmed |
| pubmed-article:1995899 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1995899 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1995899 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1995899 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1995899 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1995899 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1995899 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1995899 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1995899 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:1995899 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:1995899 | pubmed:author | pubmed-author:GatleyS JSJ | lld:pubmed |
| pubmed-article:1995899 | pubmed:author | pubmed-author:FowlerJ SJS | lld:pubmed |
| pubmed-article:1995899 | pubmed:author | pubmed-author:WolfA PAP | lld:pubmed |
| pubmed-article:1995899 | pubmed:author | pubmed-author:DeweyS LSL | lld:pubmed |
| pubmed-article:1995899 | pubmed:author | pubmed-author:DingY SYS | lld:pubmed |
| pubmed-article:1995899 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1995899 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:1995899 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1995899 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1995899 | pubmed:pagination | 767-71 | lld:pubmed |
| pubmed-article:1995899 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:1995899 | pubmed:meshHeading | pubmed-meshheading:1995899-... | lld:pubmed |
| pubmed-article:1995899 | pubmed:meshHeading | pubmed-meshheading:1995899-... | lld:pubmed |
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| pubmed-article:1995899 | pubmed:meshHeading | pubmed-meshheading:1995899-... | lld:pubmed |
| pubmed-article:1995899 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1995899 | pubmed:articleTitle | Synthesis of high specific activity (+)- and (-)-6-[18F]fluoronorepinephrine via the nucleophilic aromatic substitution reaction. | lld:pubmed |
| pubmed-article:1995899 | pubmed:affiliation | Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973. | lld:pubmed |
| pubmed-article:1995899 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1995899 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1995899 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:1995899 | lld:chembl |
