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pubmed-article:19956657pubmed:abstractTextA somatic mutation in the FOXL2 gene is reported to be present in almost all (97%; 86/89) morphologically defined, adult-type, granulosa-cell tumors (A-GCTs). This FOXL2 c.402C>G mutation changes a highly conserved cysteine residue to a tryptophan (p.C134W). It was also found in a minority of other ovarian malignant stromal tumors, but not in benign ovarian stromal tumors or unrelated ovarian tumors or breast cancers.lld:pubmed
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pubmed-article:19956657pubmed:articleTitleThe specificity of the FOXL2 c.402C>G somatic mutation: a survey of solid tumors.lld:pubmed
pubmed-article:19956657pubmed:affiliationDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.lld:pubmed
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