In cultured NIH3T3 cells, P311 binds to the transforming growth factor-beta (TGF-?)-1 latency-associated protein (LAP) and induces the myofibroblast phenotype. In this study, we determined the levels of P311 and TGF-?1 proteins in tubulointerstitial tissue of patients with different severities of immunoglobulin-A nephropathy (IgAN), and analyzed the relationships between P311 protein expression and clinical data.
Department of Nephrology, Sichuan University West China Hospital, No. 37 Guoxue Xiang, 610041 Wu Hou District, Chengdu, Sichuan Province, China. wfp2003@tom.com
