| pubmed-article:19944124 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19944124 | lifeskim:mentions | umls-concept:C1333572 | lld:lifeskim |
| pubmed-article:19944124 | lifeskim:mentions | umls-concept:C0030274 | lld:lifeskim |
| pubmed-article:19944124 | lifeskim:mentions | umls-concept:C0911014 | lld:lifeskim |
| pubmed-article:19944124 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:19944124 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:19944124 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:19944124 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:19944124 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19944124 | pubmed:dateCreated | 2010-2-1 | lld:pubmed |
| pubmed-article:19944124 | pubmed:abstractText | Ghrelin is a 28-amino-acid peptide secreted predominantly by X/A-like cells of the gastric fundus. Ghrelin increases pancreatic beta-cell proliferation and survival via sequential activation of phosphatidylinositol-3 kinase (PI3K) and Akt. The transcription regulator Foxo1 is a prominent effector of PI3K/Akt; when it is inhibited, pancreatic beta-cells are protected against fatty-acid-induced apoptosis. We investigated the role of Foxo1 in the protective effect of ghrelin under lipotoxic conditions in the MIN6 pancreatic beta-cell line. Results showed that ghrelin promoted cell proliferation and attenuated palmitate-induced apoptosis in cultured MIN6 cells. Nuclear exclusion of Foxo1 was necessary for the function of ghrelin. Treatment of MIN6 cells with palmitate and ghrelin-induced rapid nuclear exclusion and phosphorylation of Foxo1. Unlike the JNK inhibitor SP600125, Akt inhibitor IV blocked the anti-lipotoxic effect of ghrelin and stimulated Foxo1 nuclear translocation. In addition, treatment with ghrelin combined with SP600125 showed a synergistic antiapoptotic effect in palmitate-treated MIN6 cells. Ghrelin also inhibited the endoplasmic reticulum stress pathway of apoptosis in MIN6 cells, decreased expression of cytoplasmic triglyceride, and downregulated gene expression of Bcl-2-associated X (BAX), sterol-response element-binding protein 1c (SREBP1c), and C/EBP homologous protein (CHOP-10). These findings suggest that ghrelin protects pancreatic beta-cells from lipotoxicity by inhibiting the nuclear translocation of Foxo1. | lld:pubmed |
| pubmed-article:19944124 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19944124 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19944124 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19944124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19944124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19944124 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19944124 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19944124 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:19944124 | pubmed:issn | 1873-5169 | lld:pubmed |
| pubmed-article:19944124 | pubmed:author | pubmed-author:VighB JBJ | lld:pubmed |
| pubmed-article:19944124 | pubmed:author | pubmed-author:LiuYingY | lld:pubmed |
| pubmed-article:19944124 | pubmed:author | pubmed-author:ChenYingY | lld:pubmed |
| pubmed-article:19944124 | pubmed:author | pubmed-author:ZhaoHongH | lld:pubmed |
| pubmed-article:19944124 | pubmed:author | pubmed-author:ZhangDanD | lld:pubmed |
| pubmed-article:19944124 | pubmed:author | pubmed-author:XiangYingY | lld:pubmed |
| pubmed-article:19944124 | pubmed:author | pubmed-author:LiuGuoliangG | lld:pubmed |
| pubmed-article:19944124 | pubmed:author | pubmed-author:CaoCuipingC | lld:pubmed |
| pubmed-article:19944124 | pubmed:author | pubmed-author:HanLinglingL | lld:pubmed |
| pubmed-article:19944124 | pubmed:copyrightInfo | (c) 2009 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:19944124 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19944124 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:19944124 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19944124 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19944124 | pubmed:pagination | 307-14 | lld:pubmed |
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| pubmed-article:19944124 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:19944124 | pubmed:articleTitle | Inhibition of Foxo1 mediates protective effects of ghrelin against lipotoxicity in MIN6 pancreatic beta-cells. | lld:pubmed |
| pubmed-article:19944124 | pubmed:affiliation | Department of Endocrinology, First Hospital of China Medical University, No. 155, Nanjingbei Street, Heping District, Shenyang 110001, Liaoning, China. | lld:pubmed |
| pubmed-article:19944124 | pubmed:publicationType | Journal Article | lld:pubmed |
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