Linked Life Data

19940027

Source:http://linkedlifedata.com/resource/pubmed/id/19940027

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:19940027rdf:typepubmed:Citationlld:pubmed
pubmed-article:19940027lifeskim:mentionsumls-concept:C0086418lld:lifeskim
pubmed-article:19940027lifeskim:mentionsumls-concept:C0003075lld:lifeskim
pubmed-article:19940027lifeskim:mentionsumls-concept:C1335836lld:lifeskim
pubmed-article:19940027lifeskim:mentionsumls-concept:C0017262lld:lifeskim
pubmed-article:19940027lifeskim:mentionsumls-concept:C0040649lld:lifeskim
pubmed-article:19940027lifeskim:mentionsumls-concept:C1823153lld:lifeskim
pubmed-article:19940027lifeskim:mentionsumls-concept:C1621574lld:lifeskim
pubmed-article:19940027lifeskim:mentionsumls-concept:C1709059lld:lifeskim
pubmed-article:19940027lifeskim:mentionsumls-concept:C2349976lld:lifeskim
pubmed-article:19940027lifeskim:mentionsumls-concept:C1552644lld:lifeskim
pubmed-article:19940027lifeskim:mentionsumls-concept:C0441712lld:lifeskim
pubmed-article:19940027pubmed:issue2lld:pubmed
pubmed-article:19940027pubmed:dateCreated2010-1-26lld:pubmed
pubmed-article:19940027pubmed:abstractTextTwo members of the SLC26 gene family, SLC26A3 or DRA (downregulated in adenoma) and SLC26A6 (putative anion transporter 1, PAT1), are known to play a major role in apical Cl(-)/OH(-) (HCO(3)(-)) exchange process in the human intestine. We have previously shown the inhibitory effects of IFN-gamma (30 ng/ml, 24 h) on both SLC26A3 and A6 expression and promoter activity. We also demonstrated that the effects of IFN-gamma on SLC26A6 gene expression were mediated via IRF-1 transcription factor. However, the molecular mechanisms underlying the transcriptional modulation of SLC26A3 gene expression by IFN-gamma in the intestine are not known. The present studies were, therefore, designed to elucidate the signaling mechanisms and transcription factor(s) involved in mediating the inhibitory effects of IFN-gamma on DRA promoter (p--1183/+114) activity. Deletion analysis indicated that the IFN-gamma response element is located within the -1183 to -790 region, and sequence analysis of this region revealed the presence of potential gamma-activated site (GAS), a binding site (-933/-925 bp) for signal transducer and activator of transcription factor 1 (STAT1). Mutations in the potential GAS element abrogated the inhibitory effects of IFN-gamma. These studies provide evidence for the involvement of STAT1 in the inhibition of SLC26A3 gene expression by IFN-gamma in the human intestine.lld:pubmed
pubmed-article:19940027pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:languageenglld:pubmed
pubmed-article:19940027pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:citationSubsetIMlld:pubmed
pubmed-article:19940027pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19940027pubmed:statusMEDLINElld:pubmed
pubmed-article:19940027pubmed:monthFeblld:pubmed
pubmed-article:19940027pubmed:issn1522-1547lld:pubmed
pubmed-article:19940027pubmed:authorpubmed-author:DudejaPradeep...lld:pubmed
pubmed-article:19940027pubmed:authorpubmed-author:RamaswamyKris...lld:pubmed
pubmed-article:19940027pubmed:authorpubmed-author:SaksenaSeemaSlld:pubmed
pubmed-article:19940027pubmed:authorpubmed-author:GillRavinder...lld:pubmed
pubmed-article:19940027pubmed:authorpubmed-author:AlrefaiWaddah...lld:pubmed
pubmed-article:19940027pubmed:authorpubmed-author:SinglaAmikaAlld:pubmed
pubmed-article:19940027pubmed:authorpubmed-author:BansalNikhilNlld:pubmed
pubmed-article:19940027pubmed:authorpubmed-author:GoyalSoniaSlld:pubmed
pubmed-article:19940027pubmed:authorpubmed-author:KatyalShivani...lld:pubmed
pubmed-article:19940027pubmed:issnTypeElectroniclld:pubmed
pubmed-article:19940027pubmed:volume298lld:pubmed
pubmed-article:19940027pubmed:ownerNLMlld:pubmed
pubmed-article:19940027pubmed:authorsCompleteYlld:pubmed
pubmed-article:19940027pubmed:paginationG159-66lld:pubmed
pubmed-article:19940027pubmed:dateRevised2011-11-17lld:pubmed
pubmed-article:19940027pubmed:meshHeadingpubmed-meshheading:19940027...lld:pubmed
pubmed-article:19940027pubmed:meshHeadingpubmed-meshheading:19940027...lld:pubmed
pubmed-article:19940027pubmed:meshHeadingpubmed-meshheading:19940027...lld:pubmed
pubmed-article:19940027pubmed:meshHeadingpubmed-meshheading:19940027...lld:pubmed
pubmed-article:19940027pubmed:meshHeadingpubmed-meshheading:19940027...lld:pubmed
pubmed-article:19940027pubmed:meshHeadingpubmed-meshheading:19940027...lld:pubmed
pubmed-article:19940027pubmed:meshHeadingpubmed-meshheading:19940027...lld:pubmed
pubmed-article:19940027pubmed:meshHeadingpubmed-meshheading:19940027...lld:pubmed
pubmed-article:19940027pubmed:meshHeadingpubmed-meshheading:19940027...lld:pubmed
pubmed-article:19940027pubmed:meshHeadingpubmed-meshheading:19940027...lld:pubmed
pubmed-article:19940027pubmed:meshHeadingpubmed-meshheading:19940027...lld:pubmed
pubmed-article:19940027pubmed:meshHeadingpubmed-meshheading:19940027...lld:pubmed
pubmed-article:19940027pubmed:meshHeadingpubmed-meshheading:19940027...lld:pubmed
pubmed-article:19940027pubmed:meshHeadingpubmed-meshheading:19940027...lld:pubmed
pubmed-article:19940027pubmed:meshHeadingpubmed-meshheading:19940027...lld:pubmed
pubmed-article:19940027pubmed:meshHeadingpubmed-meshheading:19940027...lld:pubmed
pubmed-article:19940027pubmed:meshHeadingpubmed-meshheading:19940027...lld:pubmed
pubmed-article:19940027pubmed:meshHeadingpubmed-meshheading:19940027...lld:pubmed
pubmed-article:19940027pubmed:year2010lld:pubmed
pubmed-article:19940027pubmed:articleTitleMechanisms of transcriptional modulation of the human anion exchanger SLC26A3 gene expression by IFN-{gamma}.lld:pubmed
pubmed-article:19940027pubmed:affiliationSection of Digestive Diseases and Nutrition, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA. saksena@uic.edulld:pubmed
pubmed-article:19940027pubmed:publicationTypeJournal Articlelld:pubmed
More...