| pubmed-article:19934286 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19934286 | lifeskim:mentions | umls-concept:C1708335 | lld:lifeskim |
| pubmed-article:19934286 | lifeskim:mentions | umls-concept:C0031327 | lld:lifeskim |
| pubmed-article:19934286 | lifeskim:mentions | umls-concept:C0442027 | lld:lifeskim |
| pubmed-article:19934286 | lifeskim:mentions | umls-concept:C0005516 | lld:lifeskim |
| pubmed-article:19934286 | lifeskim:mentions | umls-concept:C0178602 | lld:lifeskim |
| pubmed-article:19934286 | lifeskim:mentions | umls-concept:C0036043 | lld:lifeskim |
| pubmed-article:19934286 | lifeskim:mentions | umls-concept:C0851347 | lld:lifeskim |
| pubmed-article:19934286 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:19934286 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:19934286 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
| pubmed-article:19934286 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:19934286 | pubmed:dateCreated | 2009-12-2 | lld:pubmed |
| pubmed-article:19934286 | pubmed:abstractText | CH4987655 (RO4987655) is an orally active and highly selective small-molecule MEK inhibitor. It potently inhibits mitogen-activated protein kinase signaling pathway activation and tumor cell growth, with an in vitro IC(50) of 5.2 nmol/L for inhibition of MEK1/2. Single-agent oral administration of CH4987655 resulted in complete tumor regressions in xenograft models. | lld:pubmed |
| pubmed-article:19934286 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19934286 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19934286 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19934286 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19934286 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19934286 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19934286 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19934286 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19934286 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19934286 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:19934286 | pubmed:issn | 1078-0432 | lld:pubmed |
| pubmed-article:19934286 | pubmed:author | pubmed-author:GoelzerPetraP | lld:pubmed |
| pubmed-article:19934286 | pubmed:author | pubmed-author:BarrettJoanne... | lld:pubmed |
| pubmed-article:19934286 | pubmed:author | pubmed-author:LeeLucyL | lld:pubmed |
| pubmed-article:19934286 | pubmed:author | pubmed-author:IshikawaYujiY | lld:pubmed |
| pubmed-article:19934286 | pubmed:author | pubmed-author:NiuHuifengH | lld:pubmed |
| pubmed-article:19934286 | pubmed:author | pubmed-author:De... | lld:pubmed |
| pubmed-article:19934286 | pubmed:author | pubmed-author:MuSongS | lld:pubmed |
| pubmed-article:19934286 | pubmed:author | pubmed-author:IshiiNobuyaN | lld:pubmed |
| pubmed-article:19934286 | pubmed:author | pubmed-author:PeckRichardR | lld:pubmed |
| pubmed-article:19934286 | pubmed:author | pubmed-author:WeissgerberGe... | lld:pubmed |
| pubmed-article:19934286 | pubmed:author | pubmed-author:RuegerRuedige... | lld:pubmed |
| pubmed-article:19934286 | pubmed:author | pubmed-author:IgawaYurikoY | lld:pubmed |
| pubmed-article:19934286 | pubmed:author | pubmed-author:DeutschJonath... | lld:pubmed |
| pubmed-article:19934286 | pubmed:author | pubmed-author:SakamotoYuuic... | lld:pubmed |
| pubmed-article:19934286 | pubmed:author | pubmed-author:Busse-ReidRac... | lld:pubmed |
| pubmed-article:19934286 | pubmed:author | pubmed-author:GimmiClaudeC | lld:pubmed |
| pubmed-article:19934286 | pubmed:author | pubmed-author:YoshimuraYash... | lld:pubmed |
| pubmed-article:19934286 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19934286 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:19934286 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:19934286 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19934286 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19934286 | pubmed:pagination | 7368-74 | lld:pubmed |
| pubmed-article:19934286 | pubmed:meshHeading | pubmed-meshheading:19934286... | lld:pubmed |
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| pubmed-article:19934286 | pubmed:meshHeading | pubmed-meshheading:19934286... | lld:pubmed |
| pubmed-article:19934286 | pubmed:meshHeading | pubmed-meshheading:19934286... | lld:pubmed |
| pubmed-article:19934286 | pubmed:meshHeading | pubmed-meshheading:19934286... | lld:pubmed |
| pubmed-article:19934286 | pubmed:meshHeading | pubmed-meshheading:19934286... | lld:pubmed |
| pubmed-article:19934286 | pubmed:meshHeading | pubmed-meshheading:19934286... | lld:pubmed |
| pubmed-article:19934286 | pubmed:meshHeading | pubmed-meshheading:19934286... | lld:pubmed |
| pubmed-article:19934286 | pubmed:meshHeading | pubmed-meshheading:19934286... | lld:pubmed |
| pubmed-article:19934286 | pubmed:meshHeading | pubmed-meshheading:19934286... | lld:pubmed |
| pubmed-article:19934286 | pubmed:meshHeading | pubmed-meshheading:19934286... | lld:pubmed |
| pubmed-article:19934286 | pubmed:meshHeading | pubmed-meshheading:19934286... | lld:pubmed |
| pubmed-article:19934286 | pubmed:meshHeading | pubmed-meshheading:19934286... | lld:pubmed |
| pubmed-article:19934286 | pubmed:meshHeading | pubmed-meshheading:19934286... | lld:pubmed |
| pubmed-article:19934286 | pubmed:meshHeading | pubmed-meshheading:19934286... | lld:pubmed |
| pubmed-article:19934286 | pubmed:meshHeading | pubmed-meshheading:19934286... | lld:pubmed |
| pubmed-article:19934286 | pubmed:meshHeading | pubmed-meshheading:19934286... | lld:pubmed |
| pubmed-article:19934286 | pubmed:meshHeading | pubmed-meshheading:19934286... | lld:pubmed |
| pubmed-article:19934286 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19934286 | pubmed:articleTitle | The safety, tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of CH4987655 in healthy volunteers: target suppression using a biomarker. | lld:pubmed |
| pubmed-article:19934286 | pubmed:affiliation | Clinical Pharmacology, Hoffman-La Roche, Nutley, New Jersey 07110, USA. lucy.lee@roche.com | lld:pubmed |
| pubmed-article:19934286 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19934286 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
