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pubmed-article:19920042pubmed:abstractTextCardiac resynchronization therapy (CRT) has been shown to reduce functional mitral regurgitation (MR). It has been proposed that the mechanism of MR reduction relates to geometric change or, alternatively, changes in left ventricular (LV) contractile function. Normal mitral valve (MV) function relies on a balance between tethering and closing forces on the MV leaflets. Functional MR results from a derangement of this force-balance relationship, and CRT may be an important modulator of MV function by its ability to enhance the force-balance relationship on the MV. We hypothesized that CRT improves the comprehensive force balance acting on the valve, including favorable changes in both geometry and LV contractile function.lld:pubmed
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pubmed-article:19920042pubmed:articleTitleMechanism of decrease in mitral regurgitation after cardiac resynchronization therapy: optimization of the force-balance relationship.lld:pubmed
pubmed-article:19920042pubmed:affiliationDivision of Cardiology, Massachusetts General Hospital, Boston, MA 02114, USA.lld:pubmed
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