| pubmed-article:19919122 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19919122 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:19919122 | lifeskim:mentions | umls-concept:C0221102 | lld:lifeskim |
| pubmed-article:19919122 | lifeskim:mentions | umls-concept:C0025519 | lld:lifeskim |
| pubmed-article:19919122 | lifeskim:mentions | umls-concept:C0005576 | lld:lifeskim |
| pubmed-article:19919122 | lifeskim:mentions | umls-concept:C1704711 | lld:lifeskim |
| pubmed-article:19919122 | lifeskim:mentions | umls-concept:C0963403 | lld:lifeskim |
| pubmed-article:19919122 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:19919122 | pubmed:dateCreated | 2009-11-20 | lld:pubmed |
| pubmed-article:19919122 | pubmed:abstractText | Metabolism of pyridalyl [2,6-dichloro-4-(3,3-dichloroallyloxy)phenyl 3-[5-(trifluoromethyl)-2-pyridyloxy]propyl ether] labeled at position 2 of the dichloropropenyl group with 14C was investigated after single oral administration to male and female rats at 5 and 500 mg/kg. Absorbed 14C was excreted into feces (68-79%), urine (8-14%), and expired air (6-10%) in all of the groups. Regarding 14C-tissue residues on the seventh day after administration, fat showed the highest levels at 0.98-2.34 ppm and 219-221 ppm with the low and high doses, respectively. 14C-Residues in other tissues accounted for 0.03-0.32 ppm at the low dose and 3-70 ppm at the high dose. The percentages of the 14C-residue in fat were 1.50-3.16% of the dose, and those of muscle and hair and skin were also relatively high, accounting for 0.49-1.20%. Total 14C-residues in the whole body were 2.95-6.80% of the dose. Fecal metabolites in male rats treated with 500 mg/kg pyridalyl were purified by a combination of chromatographic techniques, and chemical structures of 8 metabolites were identified by NMR and MS spectrometry. The biotransformation reactions in rats were proposed to be as follows: (1) epoxidation of the double bond in the dichloropropenyl group followed by hydration, dehydrochlorination, decarboxylation, and/or mercapturic acid conjugation; (2) CO2 formation after O-dealkylation of pyridalyl and its metabolites; (3) hydroxylation of C3 in the pyridyl ring; (4) O-dealkylation of the pyridyloxy and the trimethylene groups; (5) dehydrochlorination and hydration in the dichloropropenyl group. | lld:pubmed |
| pubmed-article:19919122 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19919122 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19919122 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19919122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19919122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19919122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19919122 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19919122 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:19919122 | pubmed:issn | 1520-5118 | lld:pubmed |
| pubmed-article:19919122 | pubmed:author | pubmed-author:TomigaharaYos... | lld:pubmed |
| pubmed-article:19919122 | pubmed:author | pubmed-author:KanekoHideoH | lld:pubmed |
| pubmed-article:19919122 | pubmed:author | pubmed-author:IsobeNaohikoN | lld:pubmed |
| pubmed-article:19919122 | pubmed:author | pubmed-author:NagahoriHiroh... | lld:pubmed |
| pubmed-article:19919122 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19919122 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:19919122 | pubmed:volume | 57 | lld:pubmed |
| pubmed-article:19919122 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19919122 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19919122 | pubmed:pagination | 10845-51 | lld:pubmed |
| pubmed-article:19919122 | pubmed:meshHeading | pubmed-meshheading:19919122... | lld:pubmed |
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| pubmed-article:19919122 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19919122 | pubmed:articleTitle | Metabolism of pyridalyl in rats: excretion, distribution, and biotransformation of dichloropropenyl-labeled pyridalyl. | lld:pubmed |
| pubmed-article:19919122 | pubmed:affiliation | Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., 1-98, 3-Chome, Kasugade-Naka, Konohana-Ku, Osaka 554-8558, Japan. nagahori@sc.sumitomo-chem.co.jp | lld:pubmed |
| pubmed-article:19919122 | pubmed:publicationType | Journal Article | lld:pubmed |
