| pubmed-article:19918367 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19918367 | lifeskim:mentions | umls-concept:C1517631 | lld:lifeskim |
| pubmed-article:19918367 | lifeskim:mentions | umls-concept:C1517806 | lld:lifeskim |
| pubmed-article:19918367 | lifeskim:mentions | umls-concept:C0242640 | lld:lifeskim |
| pubmed-article:19918367 | lifeskim:mentions | umls-concept:C0060274 | lld:lifeskim |
| pubmed-article:19918367 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:19918367 | lifeskim:mentions | umls-concept:C0024488 | lld:lifeskim |
| pubmed-article:19918367 | lifeskim:mentions | umls-concept:C0563532 | lld:lifeskim |
| pubmed-article:19918367 | lifeskim:mentions | umls-concept:C1450054 | lld:lifeskim |
| pubmed-article:19918367 | lifeskim:mentions | umls-concept:C1548675 | lld:lifeskim |
| pubmed-article:19918367 | pubmed:dateCreated | 2009-11-17 | lld:pubmed |
| pubmed-article:19918367 | pubmed:abstractText | This study aims to evaluate the multidrug resistance (MDR) reversal activity by magnetic nanoparticles of Fe3O4 (MNPs-Fe3O4) and 5-bromotetrandrine (BrTet) MDR cell line K562/A02 solitarily or symphysially. The proliferation of K562 and K562/A02 cells and the cytotoxicity on peripheral blood mononuclear cells (PMBCs) were evaluated by MTT assay. Cellular accumulation of daunorubicin (DNR) was analyzed by flow cytometry. Real-time polymerase chain reaction and Western blotting analyses were performed to examine the mRNA and protein levels of mdr1, respectively. The results showed that the combination of MNPs-Fe3O4 and BrTet with effective concentrations significantly increased cytotoxicity against MDR cell line K562/A02. Both BrTet and MNPs-Fe3O4 increased the intracellular DNR accumulation in the K562/A02 cell line, and downregulated the level of mdr1 gene and expression of P-glycoprotein. Furthermore, the combination did not have significant cytotoxicity in PMBCs. We propose that MNPs-Fe3O4 conjugated with DNR and BrTet probably have synergetic effects on MDR reversal. | lld:pubmed |
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| pubmed-article:19918367 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19918367 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19918367 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19918367 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19918367 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19918367 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19918367 | pubmed:issn | 1178-2013 | lld:pubmed |
| pubmed-article:19918367 | pubmed:author | pubmed-author:HawW WWW | lld:pubmed |
| pubmed-article:19918367 | pubmed:author | pubmed-author:WangXuemeiX | lld:pubmed |
| pubmed-article:19918367 | pubmed:author | pubmed-author:GaoFengF | lld:pubmed |
| pubmed-article:19918367 | pubmed:author | pubmed-author:XuWenlinW | lld:pubmed |
| pubmed-article:19918367 | pubmed:author | pubmed-author:ChengJianJ | lld:pubmed |
| pubmed-article:19918367 | pubmed:author | pubmed-author:LiXiaomaoX | lld:pubmed |
| pubmed-article:19918367 | pubmed:author | pubmed-author:DingJiahuaJ | lld:pubmed |
| pubmed-article:19918367 | pubmed:author | pubmed-author:WuWeiweiW | lld:pubmed |
| pubmed-article:19918367 | pubmed:author | pubmed-author:GaoChongC | lld:pubmed |
| pubmed-article:19918367 | pubmed:author | pubmed-author:ChenBao-anBA | lld:pubmed |
| pubmed-article:19918367 | pubmed:author | pubmed-author:XiaGuohuaG | lld:pubmed |
| pubmed-article:19918367 | pubmed:author | pubmed-author:LiuLijieL | lld:pubmed |
| pubmed-article:19918367 | pubmed:author | pubmed-author:SunXinchenX | lld:pubmed |
| pubmed-article:19918367 | pubmed:author | pubmed-author:ChenNingnaN | lld:pubmed |
| pubmed-article:19918367 | pubmed:author | pubmed-author:ChenWenjiW | lld:pubmed |
| pubmed-article:19918367 | pubmed:author | pubmed-author:SunYunyuY | lld:pubmed |
| pubmed-article:19918367 | pubmed:author | pubmed-author:SongHuihuiH | lld:pubmed |
| pubmed-article:19918367 | pubmed:author | pubmed-author:XuCuirongC | lld:pubmed |
| pubmed-article:19918367 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19918367 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:19918367 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19918367 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19918367 | pubmed:pagination | 209-16 | lld:pubmed |
| pubmed-article:19918367 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:19918367 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19918367 | pubmed:articleTitle | Effect of magnetic nanoparticles of Fe3O4 and 5-bromotetrandrine on reversal of multidrug resistance in K562/A02 leukemic cells. | lld:pubmed |
| pubmed-article:19918367 | pubmed:affiliation | Department of Hematology, The Affiliated Zhongda Hospital, Southeast University, Nanjing 210009, People's Republic of China. | lld:pubmed |
| pubmed-article:19918367 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19918367 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19918367 | lld:pubmed |
