| pubmed-article:19917680 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19917680 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:19917680 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:19917680 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:19917680 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:19917680 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:19917680 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:19917680 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:19917680 | lifeskim:mentions | umls-concept:C0678558 | lld:lifeskim |
| pubmed-article:19917680 | lifeskim:mentions | umls-concept:C1515021 | lld:lifeskim |
| pubmed-article:19917680 | lifeskim:mentions | umls-concept:C1880371 | lld:lifeskim |
| pubmed-article:19917680 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:19917680 | pubmed:dateCreated | 2009-11-20 | lld:pubmed |
| pubmed-article:19917680 | pubmed:abstractText | IL-17-secreting CD8 T cells (Tc17) have been described in several settings, but little is known regarding their functional characteristics. While Tc1 cells produced IFN-gamma and efficiently killed targets, Tc17 cells lacked lytic function in vitro. Interestingly, the small numbers of IFN-gamma-positive or IL-17/IFN-gamma-double-positive cells generated under Tc17 conditions also lacked lytic activity and expressed a similar pattern of cell surface proteins to IL-17-producing cells. As is the case for Th17 (CD4) cells, STAT3 is important for Tc17 polarization, both in vitro and in vivo. Adoptive transfer of highly purified, Ag-specific IL-17-secreting Tc17 cells into Ag-bearing hosts resulted in near complete conversion to an IFN-gamma-secreting phenotype and substantial pulmonary pathology, demonstrating functional plasticity. Tc17 also accumulated to a greater extent than did Tc1 cells, suggesting that adoptive transfer of CD8 T cells cultured in Tc17 conditions may have therapeutic potential for diseases in which IFN-gamma-producing cells are desired. | lld:pubmed |
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| pubmed-article:19917680 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:19917680 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:19917680 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19917680 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:19917680 | pubmed:issn | 1550-6606 | lld:pubmed |
| pubmed-article:19917680 | pubmed:author | pubmed-author:LinTzou-YienT... | lld:pubmed |
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| pubmed-article:19917680 | pubmed:author | pubmed-author:AdlerAdam JAJ | lld:pubmed |
| pubmed-article:19917680 | pubmed:author | pubmed-author:AndersRobert... | lld:pubmed |
| pubmed-article:19917680 | pubmed:author | pubmed-author:WadaSatoshiS | lld:pubmed |
| pubmed-article:19917680 | pubmed:author | pubmed-author:HuangChing-Ta... | lld:pubmed |
| pubmed-article:19917680 | pubmed:author | pubmed-author:YenHung-RongH... | lld:pubmed |
| pubmed-article:19917680 | pubmed:author | pubmed-author:GrossoJoseph... | lld:pubmed |
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| pubmed-article:19917680 | pubmed:author | pubmed-author:BrunoTullia... | lld:pubmed |
| pubmed-article:19917680 | pubmed:author | pubmed-author:LiangKai-LiKL | lld:pubmed |
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| pubmed-article:19917680 | pubmed:author | pubmed-author:ChanSiaw-LiSL | lld:pubmed |
| pubmed-article:19917680 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19917680 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:19917680 | pubmed:volume | 183 | lld:pubmed |
| pubmed-article:19917680 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19917680 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19917680 | pubmed:pagination | 7161-8 | lld:pubmed |
| pubmed-article:19917680 | pubmed:dateRevised | 2011-7-28 | lld:pubmed |
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| pubmed-article:19917680 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19917680 | pubmed:articleTitle | Tc17 CD8 T cells: functional plasticity and subset diversity. | lld:pubmed |
