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pubmed-article:1991114pubmed:abstractTextA complete relaxation matrix approach employing a matrix eigenvalue/eigenvector solution to the Bloch equations is used to evaluate the NMR solution structure of a tandemly positioned G.A double mismatch decamer oligodeoxyribonucleotide duplex, d(CCAAGATTGG)2. An iterative refinement method using a hybrid relaxation matrix combined with restrained molecular dynamics calculations is shown to provide structures having good agreement with the experimentally derived structures. Distances incorporated into the MD simulations have been calculated from the relaxation rate matrix evaluated from a hybrid NOESY volume matrix whose elements are obtained from the merging of experimental and calculated NOESY intensities. Starting from both A- and B-DNA and mismatch syn and anti models, it is possible to calculate structures that are in good atomic RMS agreement with each other (less than 1.6 A RMS) but differ from the reported crystal structure (greater than 3.6 A). Importantly, the hybrid matrix derived structures are in excellent agreement with the experimental solution conformation as determined by comparison of the 200-ms simulated and experimental NOESY spectra, while the crystallographic data provide spectra that are grossly different.lld:pubmed
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pubmed-article:1991114pubmed:pagination1323-34lld:pubmed
pubmed-article:1991114pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:1991114pubmed:articleTitleNMR structural refinement of a tandem G.A mismatched decamer d(CCAAGATTGG)2 via the hybrid matrix procedure.lld:pubmed
pubmed-article:1991114pubmed:affiliationDepartment of Chemistry, Purdue University, West Lafayette, Indiana 47907.lld:pubmed
pubmed-article:1991114pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1991114pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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