Linked Life Data

19908249

Source:http://linkedlifedata.com/resource/pubmed/id/19908249

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SubjectPredicateObjectContext
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pubmed-article:19908249pubmed:abstractTextLeptin, the hormonal product of the obese (ob) gene, circulates in the blood at levels paralleling those of fat reserves and regulates satiety. In cattle, leptin has also been implicated in the control of ovarian function, but its local production in the ovary and role in the control of ovarian function in autocrine/paracrine manner is unknown. The aims of this study were to document the expression of leptin and its receptor (Ob-R) in detail in bovine corpus luteum (CL) obtained from different stages of the oestrous cycle and during pregnancy-and to determine if the leptin/Ob-R system is expressed clearly in bovine follicles during final growth to preovulatory follicles. Real-time RT-PCR (qPCR) was applied to investigate mRNA expression of examined factors. In general, we demonstrated leptin and its receptor transcripts and leptin protein are consistent with in vivo luteinisation of bovine CL and decline coincidental with luteal regression. The highest co-expression of leptin/Ob-R system was observed in TI and GC of the smallest follicles with E2 concentration <0.5 ng/ml followed by significant down regulation in growing follicles with the increase of follicular size and E2 content in the follicular fluid. Furthermore, expression of the leptin/Ob-R system does not show any significant variation in the CL throughout pregnancy. To conclude, our results are the first to demonstrate the possible involvement of locally produced leptin/Ob-R system in the bovine ovary, suggesting roles in the function and/or development of the CL and growth of small follicles in an autocrine/paracrine fashion.lld:pubmed
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pubmed-article:19908249pubmed:authorpubmed-author:SarkarMMlld:pubmed
pubmed-article:19908249pubmed:authorpubmed-author:BerishaBajram...lld:pubmed
pubmed-article:19908249pubmed:authorpubmed-author:SchamsDieterDlld:pubmed
pubmed-article:19908249pubmed:authorpubmed-author:MeyerHeinrich...lld:pubmed
pubmed-article:19908249pubmed:authorpubmed-author:SchilffarthSt...lld:pubmed
pubmed-article:19908249pubmed:copyrightInfo(c) 2009 Wiley-Liss, Inc.lld:pubmed
pubmed-article:19908249pubmed:issnTypeElectroniclld:pubmed
pubmed-article:19908249pubmed:volume77lld:pubmed
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pubmed-article:19908249pubmed:pagination174-81lld:pubmed
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pubmed-article:19908249pubmed:articleTitleThe expression of leptin and its receptor during different physiological stages in the bovine ovary.lld:pubmed
pubmed-article:19908249pubmed:affiliationPhysiology Weihenstephan, Technical University Munich, Freising, Germany. msarkar24@gmail.comlld:pubmed
pubmed-article:19908249pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19908249pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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