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pubmed-article:19903807pubmed:abstractTextRestoring p53 function by antagonizing its interaction with the negative regulator MDM2 is an appealing nongenotoxic approach to treating tumors with wild-type p53. Mutational inactivation of p53 is rare in neuroblastoma tumors at diagnosis and occurs in only a subset of multidrug-resistant neuroblastomas.lld:pubmed
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pubmed-article:19903807pubmed:articleTitleAntitumor activity of the selective MDM2 antagonist nutlin-3 against chemoresistant neuroblastoma with wild-type p53.lld:pubmed
pubmed-article:19903807pubmed:affiliationCenter for Medical Genetics, Ghent University Hospital, Ghent, Belgium. tom.vanmaerken@ugent.belld:pubmed
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