| pubmed-article:1990282 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1990282 | lifeskim:mentions | umls-concept:C0521119 | lld:lifeskim |
| pubmed-article:1990282 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:1990282 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:1990282 | lifeskim:mentions | umls-concept:C0205054 | lld:lifeskim |
| pubmed-article:1990282 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:1990282 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:1990282 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:1990282 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:1990282 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:1990282 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1990282 | pubmed:dateCreated | 1991-3-4 | lld:pubmed |
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| pubmed-article:1990282 | pubmed:abstractText | A complex cell culture environment has been shown to maintain the differentiated state of hepatocytes, yet the mechanisms by which environmental cues selectively maintain liver-specific gene transcription have been unknown. In this paper we show that the hepatic environment regulates the activities of at least three liver-enriched transcription factors, eE-TF, eG-TF/HNF3, and eH-TF, that activate the mouse serum albumin enhancer. eE-TF is a heat-stable factor that has a DNA-binding specificity similar to that of the liver transcription factor C/EBP, but is a distinct protein. eG-TF/HNF3 contributes to the liver-specific transcription of several other serum protein genes. eH-TF binds to a TGTTTGC sequence that occurs at regulatory sites of the albumin promoter, the hepatitis B virus enhancer, and other hepatic genes. eE-TF, eG-TF/HNF3, and eH-TF are regulated by different combinations of the following cell culture conditions: a hormonally defined serum-free medium; an extracellular matrix gel; and a transformation-competent simian virus 40 large T antigen. We propose a regulatory network model to explain how cues from the cell lineage and the extracellular environment coordinately help maintain the activities of transcription factors involved in hepatocyte differentiation. | lld:pubmed |
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| pubmed-article:1990282 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1990282 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1990282 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1990282 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1990282 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:1990282 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:1990282 | pubmed:author | pubmed-author:LimJ SJS | lld:pubmed |
| pubmed-article:1990282 | pubmed:author | pubmed-author:ZaretK SKS | lld:pubmed |
| pubmed-article:1990282 | pubmed:author | pubmed-author:DiPersioC MCM | lld:pubmed |
