| pubmed-article:19893743 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19893743 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:19893743 | lifeskim:mentions | umls-concept:C0010674 | lld:lifeskim |
| pubmed-article:19893743 | lifeskim:mentions | umls-concept:C0035204 | lld:lifeskim |
| pubmed-article:19893743 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:19893743 | lifeskim:mentions | umls-concept:C0031676 | lld:lifeskim |
| pubmed-article:19893743 | lifeskim:mentions | umls-concept:C0521117 | lld:lifeskim |
| pubmed-article:19893743 | lifeskim:mentions | umls-concept:C1519316 | lld:lifeskim |
| pubmed-article:19893743 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:19893743 | lifeskim:mentions | umls-concept:C0679199 | lld:lifeskim |
| pubmed-article:19893743 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:19893743 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:19893743 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:19893743 | pubmed:dateCreated | 2009-11-6 | lld:pubmed |
| pubmed-article:19893743 | pubmed:abstractText | The aim of this study was to search for lipid signatures in blood plasma from cystic fibrosis (CF) patients using a novel MALDI-TOF-ClinProTools strategy, initially developed for protein analysis, and thin layer chromatography coupled to MALDI-TOF (TLC-MALDI). Samples from 33 CF patients and 18 healthy children were subjected to organic extraction and column chromatography separation of lipid classes. Extracts were analyzed by MALDI-TOF, ion signatures were compared by the ClinProTools software and by parallel statistical analyses. Relevant peaks were identified by LC-MSn. The ensemble of analyses provided 11 and 4 peaks differentially displayed in CF vs healthy and in mild vs severe patients respectively. Ten ions were significantly decreased in all patients, corresponding to 4 lysophosphatidylcholine (18:0, 18:2, 20:3, and 20:5) and 6 phosphatidylcholine (36:5, O-38:0, 38:4, 38:5, 38:6, and P-40:1) species. One sphingolipid, SM(d18:0), was significantly increased in all patients. Four PC forms (36:3, 36:5, 38:5, and 38:6) were consistently downregulated in severe vs mild patients. These observations were confirmed by TLC-MALDI. These results suggest that plasma phospholipid signatures may be able to discriminate mild and severe forms of CF, and show for the first time MALDI-TOF-ClinProTools as a suitable methodology for the search of lipid markers in CF. | lld:pubmed |
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| pubmed-article:19893743 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19893743 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19893743 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19893743 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19893743 | pubmed:issn | 1932-6203 | lld:pubmed |
| pubmed-article:19893743 | pubmed:author | pubmed-author:EdelmanAleksa... | lld:pubmed |
| pubmed-article:19893743 | pubmed:author | pubmed-author:Sermet-Gaudel... | lld:pubmed |
| pubmed-article:19893743 | pubmed:author | pubmed-author:JaisJean-Phil... | lld:pubmed |
| pubmed-article:19893743 | pubmed:author | pubmed-author:OlleroMarioM | lld:pubmed |
| pubmed-article:19893743 | pubmed:author | pubmed-author:PiomelliDanie... | lld:pubmed |
| pubmed-article:19893743 | pubmed:author | pubmed-author:SchuerenbergM... | lld:pubmed |
| pubmed-article:19893743 | pubmed:author | pubmed-author:SandsDorotaD | lld:pubmed |
| pubmed-article:19893743 | pubmed:author | pubmed-author:NowakowskaAnn... | lld:pubmed |
| pubmed-article:19893743 | pubmed:author | pubmed-author:AstaritaGiuse... | lld:pubmed |
| pubmed-article:19893743 | pubmed:author | pubmed-author:GuerreraIda... | lld:pubmed |
| pubmed-article:19893743 | pubmed:author | pubmed-author:ColasJulienJ | lld:pubmed |
| pubmed-article:19893743 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19893743 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:19893743 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19893743 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19893743 | pubmed:pagination | e7735 | lld:pubmed |
| pubmed-article:19893743 | pubmed:dateRevised | 2010-9-27 | lld:pubmed |
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