| pubmed-article:19892920 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19892920 | lifeskim:mentions | umls-concept:C0009170 | lld:lifeskim |
| pubmed-article:19892920 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:19892920 | lifeskim:mentions | umls-concept:C0243192 | lld:lifeskim |
| pubmed-article:19892920 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:19892920 | lifeskim:mentions | umls-concept:C1552514 | lld:lifeskim |
| pubmed-article:19892920 | lifeskim:mentions | umls-concept:C0336809 | lld:lifeskim |
| pubmed-article:19892920 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19892920 | pubmed:dateCreated | 2010-1-20 | lld:pubmed |
| pubmed-article:19892920 | pubmed:abstractText | sigma-Receptor (sigmaR) antagonists have been reported to block certain effects of psychostimulant drugs. The present study examined the effects of sigmaR ligands in rats trained to self-administer cocaine (0.032-1.0 mg/kg/inj i.v.) under fixed-ratio 5-response schedules of reinforcement. Maximal rates of responding were maintained by 0.32 mg/kg/inj cocaine, or by the sigmaR agonists, 1,3-di-(2-tolyl)guanidine (DTG; 1.0 mg/kg/inj) or 2-(4-morpholinethyl) 1-phenylcyclohexane-1-carboxylate hydrochloride (PRE-084; 0.32 mg/kg/inj), when substituted for cocaine. Lower response rates were maintained at higher and lower doses of the compounds. No dose of the sigmaR antagonists [N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamine (BD 1008), N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine (BD 1047), N-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine (BD 1063)] maintained responding appreciably above levels obtained when responding had no consequences. Presession treatment with sigmaR agonists dose-dependently shifted the cocaine self-administration dose-effect curve leftward. The dopamine-uptake inhibitor, (-)-2beta-carbomethoxy-3beta-(4-fluorophenyl)tropane (WIN 35,428), dose-dependently shifted the DTG and PRE-084 self-administration dose-effect curves leftward. Treatment with the sigmaR antagonists dose-dependently decreased response rates maintained by DTG or PRE-084, but did not affect cocaine self-administration. Response rates maintained by maximally effective DTG or PRE-084 doses were decreased by sigmaR antagonists at lower doses than those that decreased response rates maintained by food reinforcement. Although sigmaR antagonists block some cocaine-induced effects, the lack of effect on cocaine self-administration suggests that the primary reinforcing effects of cocaine do not involve direct effects at sigmaRs. However, the self-administration of sigmaR agonists in cocaine-trained subjects, facilitation of cocaine self-administration by sigmaR-agonist pretreatment, and the facilitation of sigmaR-agonist self-administration by WIN 35,428, together suggest enhanced abuse-related effects resulting from concomitant dopaminergically mediated actions and sigmaR-mediated actions of the drugs. | lld:pubmed |
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| pubmed-article:19892920 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19892920 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19892920 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19892920 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19892920 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:19892920 | pubmed:issn | 1521-0103 | lld:pubmed |
| pubmed-article:19892920 | pubmed:author | pubmed-author:KatzJonathan... | lld:pubmed |
| pubmed-article:19892920 | pubmed:author | pubmed-author:TandaGianluig... | lld:pubmed |
| pubmed-article:19892920 | pubmed:author | pubmed-author:HiranitaTakat... | lld:pubmed |
| pubmed-article:19892920 | pubmed:author | pubmed-author:SotoPaul LPL | lld:pubmed |
| pubmed-article:19892920 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19892920 | pubmed:volume | 332 | lld:pubmed |
| pubmed-article:19892920 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19892920 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19892920 | pubmed:pagination | 515-24 | lld:pubmed |
| pubmed-article:19892920 | pubmed:dateRevised | 2011-7-22 | lld:pubmed |
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| pubmed-article:19892920 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:19892920 | pubmed:articleTitle | Reinforcing effects of sigma-receptor agonists in rats trained to self-administer cocaine. | lld:pubmed |
| pubmed-article:19892920 | pubmed:affiliation | Psychobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA. | lld:pubmed |
| pubmed-article:19892920 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19892920 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19892920 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19892920 | lld:pubmed |
