| pubmed-article:19891958 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19891958 | lifeskim:mentions | umls-concept:C0206131 | lld:lifeskim |
| pubmed-article:19891958 | lifeskim:mentions | umls-concept:C0596843 | lld:lifeskim |
| pubmed-article:19891958 | lifeskim:mentions | umls-concept:C0166417 | lld:lifeskim |
| pubmed-article:19891958 | lifeskim:mentions | umls-concept:C0920563 | lld:lifeskim |
| pubmed-article:19891958 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:19891958 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:19891958 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:19891958 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:19891958 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:19891958 | lifeskim:mentions | umls-concept:C0106580 | lld:lifeskim |
| pubmed-article:19891958 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:19891958 | pubmed:dateCreated | 2009-11-30 | lld:pubmed |
| pubmed-article:19891958 | pubmed:abstractText | Insulin resistance is partly due to suppression of insulin-induced glucose uptake into adipocytes. The uptake is dependent on adipocyte differentiation, which is controlled at mRNA transcription level. The peroxisome proliferator-activated receptor (PPAR), a ligand-regulated nuclear receptor, is involved in the differentiation. Many food-derived compounds serve as ligands to activate or inactivate PPAR. In this study, we demonstrated that bixin and norbixin (annatto extracts) activate PPARgamma by luciferase reporter assay using GAL4-PPAR chimera proteins. To examine the effects of bixin on adipocytes, 3T3-L1 adipocytes were treated with bixin or norbixin. The treatment induced mRNA expression of PPARgamma target genes such as adipocyte-specific fatty acid-binding protein (aP2), lipoprotein lipase (LPL), and adiponectin in differentiated 3T3-L1 adipocytes and enhanced insulin-dependent glucose uptake. The observations indicate that bixin acts as an agonist of PPARgamma and enhances insulin sensitivity in 3T3-L1 adipocytes, suggesting that bixin is a valuable food-derived compound as a PPAR ligand to regulate lipid metabolism and to ameliorate metabolic syndrome. | lld:pubmed |
| pubmed-article:19891958 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19891958 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19891958 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19891958 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19891958 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19891958 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19891958 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19891958 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19891958 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19891958 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19891958 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19891958 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19891958 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:19891958 | pubmed:issn | 1090-2104 | lld:pubmed |
| pubmed-article:19891958 | pubmed:author | pubmed-author:LeeJoo-YoungJ... | lld:pubmed |
| pubmed-article:19891958 | pubmed:author | pubmed-author:TakahashiNobu... | lld:pubmed |
| pubmed-article:19891958 | pubmed:author | pubmed-author:KawadaTeruoT | lld:pubmed |
| pubmed-article:19891958 | pubmed:author | pubmed-author:GotoTsuyoshiT | lld:pubmed |
| pubmed-article:19891958 | pubmed:author | pubmed-author:TaimatsuAkiA | lld:pubmed |
| pubmed-article:19891958 | pubmed:author | pubmed-author:KimYoung-IlYI | lld:pubmed |
| pubmed-article:19891958 | pubmed:author | pubmed-author:KusudoTatsuya... | lld:pubmed |
| pubmed-article:19891958 | pubmed:author | pubmed-author:EgawaKahoriK | lld:pubmed |
| pubmed-article:19891958 | pubmed:author | pubmed-author:HiraiShizukaS | lld:pubmed |
| pubmed-article:19891958 | pubmed:author | pubmed-author:UemuraTakuT | lld:pubmed |
| pubmed-article:19891958 | pubmed:author | pubmed-author:SakamotoTomoy... | lld:pubmed |
| pubmed-article:19891958 | pubmed:author | pubmed-author:KatohSotaS | lld:pubmed |
| pubmed-article:19891958 | pubmed:author | pubmed-author:OhyaneChieC | lld:pubmed |
| pubmed-article:19891958 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19891958 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:19891958 | pubmed:volume | 390 | lld:pubmed |
| pubmed-article:19891958 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19891958 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19891958 | pubmed:pagination | 1372-6 | lld:pubmed |
| pubmed-article:19891958 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:19891958 | pubmed:meshHeading | pubmed-meshheading:19891958... | lld:pubmed |
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| pubmed-article:19891958 | pubmed:meshHeading | pubmed-meshheading:19891958... | lld:pubmed |
| pubmed-article:19891958 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19891958 | pubmed:articleTitle | Bixin regulates mRNA expression involved in adipogenesis and enhances insulin sensitivity in 3T3-L1 adipocytes through PPARgamma activation. | lld:pubmed |
| pubmed-article:19891958 | pubmed:affiliation | Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji 611-0011, Japan. | lld:pubmed |
| pubmed-article:19891958 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19891958 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19891958 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19891958 | lld:pubmed |
