| pubmed-article:19890848 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19890848 | lifeskim:mentions | umls-concept:C2826593 | lld:lifeskim |
| pubmed-article:19890848 | lifeskim:mentions | umls-concept:C1171346 | lld:lifeskim |
| pubmed-article:19890848 | lifeskim:mentions | umls-concept:C0243045 | lld:lifeskim |
| pubmed-article:19890848 | lifeskim:mentions | umls-concept:C2718191 | lld:lifeskim |
| pubmed-article:19890848 | lifeskim:mentions | umls-concept:C1150557 | lld:lifeskim |
| pubmed-article:19890848 | lifeskim:mentions | umls-concept:C1414356 | lld:lifeskim |
| pubmed-article:19890848 | lifeskim:mentions | umls-concept:C2826592 | lld:lifeskim |
| pubmed-article:19890848 | lifeskim:mentions | umls-concept:C1417775 | lld:lifeskim |
| pubmed-article:19890848 | lifeskim:mentions | umls-concept:C1710236 | lld:lifeskim |
| pubmed-article:19890848 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:19890848 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:19890848 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:19890848 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:19890848 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19890848 | pubmed:dateCreated | 2009-12-3 | lld:pubmed |
| pubmed-article:19890848 | pubmed:abstractText | Self-renewal of pluripotent human embryonic stem (hES) cells utilizes an abbreviated cell cycle that bypasses E2F/pRB-dependent growth control. We investigated whether self-renewal is alternatively regulated by cyclin/CDK phosphorylation of the p220(NPAT)/HiNF-P complex to activate histone gene expression at the G1/S phase transition. We show that cyclin D2 is prominently expressed in pluripotent hES cells, but cyclin D1 eclipses cyclin D2 during differentiation. Depletion of cyclin D2 or p220(NPAT) causes a cell cycle defect in G1 reflected by diminished phosphorylation of p220(NPAT), decreased cell cycle dependent histone H4 expression and reduced S phase progression. Thus, cyclin D2 and p220(NPAT) are principal cell cycle regulators that determine competency for self-renewal in pluripotent hES cells. While pRB/E2F checkpoint control is relinquished in human ES cells, fidelity of physiological regulation is secured by cyclin D2 dependent activation of the p220(NPAT)/HiNF-P mechanism that may explain perpetual proliferation of hES cells without transformation or tumorigenesis. | lld:pubmed |
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| pubmed-article:19890848 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19890848 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19890848 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19890848 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19890848 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19890848 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:19890848 | pubmed:issn | 1097-4652 | lld:pubmed |
| pubmed-article:19890848 | pubmed:author | pubmed-author:SteinGary SGS | lld:pubmed |
| pubmed-article:19890848 | pubmed:author | pubmed-author:SteinJanet... | lld:pubmed |
| pubmed-article:19890848 | pubmed:author | pubmed-author:LianJane BJB | lld:pubmed |
| pubmed-article:19890848 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:19890848 | pubmed:author | pubmed-author:BeckerKlaus... | lld:pubmed |
| pubmed-article:19890848 | pubmed:author | pubmed-author:GhulePrachi... | lld:pubmed |
| pubmed-article:19890848 | pubmed:copyrightInfo | (c) 2009 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:19890848 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19890848 | pubmed:volume | 222 | lld:pubmed |
| pubmed-article:19890848 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19890848 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19890848 | pubmed:pagination | 456-64 | lld:pubmed |
