| pubmed-article:19888328 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19888328 | lifeskim:mentions | umls-concept:C0152314 | lld:lifeskim |
| pubmed-article:19888328 | lifeskim:mentions | umls-concept:C0004927 | lld:lifeskim |
| pubmed-article:19888328 | lifeskim:mentions | umls-concept:C0034809 | lld:lifeskim |
| pubmed-article:19888328 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:19888328 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:19888328 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:19888328 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:19888328 | pubmed:dateCreated | 2009-11-5 | lld:pubmed |
| pubmed-article:19888328 | pubmed:abstractText | The Glucocorticoid Receptor (GR) is a transcription factor ubiquitously expressed in the brain. Activation of brain GRs by high levels of glucocorticoid (GC) hormones modifies a large variety of physiological and pathological-related behaviors. Unfortunately the specific cellular targets of GR-mediated behavioral effects of GC are still largely unknown. To address this issue, we generated a mutated form of the GR called DeltaGR. DeltaGR is a constitutively transcriptionally active form of the GR that is localized in the nuclei and activates transcription without binding to glucocorticoids. Using the tetracycline-regulated system (Tet-OFF), we developed an inducible transgenic approach that allows the expression of the DeltaGR in specific brain areas. We focused our study on a mouse line that expressed DeltaGR almost selectively in the glutamatergic neurons of the dentate gyrus (DG) of the hippocampus. This restricted expression of the DeltaGR increased anxiety-related behaviors without affecting other behaviors that could indirectly influence performance in anxiety-related tests. This behavioral phenotype was also associated with an up-regulation of the MAPK signaling pathway and Egr-1 protein in the DG. These findings identify glutamatergic neurons in the DG as one of the cellular substrate of stress-related pathologies. | lld:pubmed |
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| pubmed-article:19888328 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19888328 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19888328 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19888328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19888328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19888328 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19888328 | pubmed:issn | 1932-6203 | lld:pubmed |
| pubmed-article:19888328 | pubmed:author | pubmed-author:PiazzaPier... | lld:pubmed |
| pubmed-article:19888328 | pubmed:author | pubmed-author:CostetPierreP | lld:pubmed |
| pubmed-article:19888328 | pubmed:author | pubmed-author:Rougé-PontFra... | lld:pubmed |
| pubmed-article:19888328 | pubmed:author | pubmed-author:RevestJean-Mi... | lld:pubmed |
| pubmed-article:19888328 | pubmed:author | pubmed-author:Di... | lld:pubmed |
| pubmed-article:19888328 | pubmed:author | pubmed-author:SarrazinNadèg... | lld:pubmed |
| pubmed-article:19888328 | pubmed:author | pubmed-author:Roullot-Lacar... | lld:pubmed |
| pubmed-article:19888328 | pubmed:author | pubmed-author:Le RouxAnneA | lld:pubmed |
