| pubmed-article:19880523 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19880523 | lifeskim:mentions | umls-concept:C0532128 | lld:lifeskim |
| pubmed-article:19880523 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:19880523 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:19880523 | lifeskim:mentions | umls-concept:C0762314 | lld:lifeskim |
| pubmed-article:19880523 | lifeskim:mentions | umls-concept:C0439851 | lld:lifeskim |
| pubmed-article:19880523 | lifeskim:mentions | umls-concept:C1552596 | lld:lifeskim |
| pubmed-article:19880523 | lifeskim:mentions | umls-concept:C1947931 | lld:lifeskim |
| pubmed-article:19880523 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19880523 | pubmed:dateCreated | 2009-12-28 | lld:pubmed |
| pubmed-article:19880523 | pubmed:abstractText | Serine-threonine kinase receptor-associated protein (STRAP) interacts with transforming growth factor beta (TGF-beta) receptors and inhibits TGF-beta signaling. Here, we identify STRAP as an interacting partner of ASK1 (apoptosis signal-regulating kinase 1). The association between ASK1 and STRAP is mediated through the C-terminal domain of ASK1 and the fourth and sixth WD40 repeats of STRAP. Using cysteine-to-serine amino acid substitution mutants of ASK1 (C1005S, C1351S, C1360S, and C1351S/C1360S) and STRAP (C152S, C270S, and C152S/C270S), we demonstrated that Cys(1351) and Cys(1360) of ASK1 and Cys(152) and Cys(270) of STRAP are required for ASK1-STRAP binding. ASK1 phosphorylated STRAP at Thr(175) and Ser(179), suggesting a potential role for STRAP phosphorylation in ASK1 activity regulation. Expression of wild-type STRAP, but not STRAP mutants (C152S/C270S and T175A/S179A), inhibited ASK1-mediated signaling to both JNK and p38 kinases by stabilizing complex formation between ASK1 and its negative regulators, thioredoxin and 14-3-3, or decreasing complex formation between ASK1 and its substrate MKK3. In addition, STRAP suppressed H(2)O(2)-mediated apoptosis in a dose-dependent manner by inhibiting ASK1 activity through direct interaction. These results suggest that STRAP can act as a negative regulator of ASK1. | lld:pubmed |
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| pubmed-article:19880523 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19880523 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19880523 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19880523 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19880523 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19880523 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:19880523 | pubmed:issn | 1083-351X | lld:pubmed |
| pubmed-article:19880523 | pubmed:author | pubmed-author:SeongHyun-AHA | lld:pubmed |
| pubmed-article:19880523 | pubmed:author | pubmed-author:HaHyunjungH | lld:pubmed |
| pubmed-article:19880523 | pubmed:author | pubmed-author:JungHaiyoungH | lld:pubmed |
| pubmed-article:19880523 | pubmed:author | pubmed-author:ManoharanRavi... | lld:pubmed |
| pubmed-article:19880523 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19880523 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:19880523 | pubmed:volume | 285 | lld:pubmed |
| pubmed-article:19880523 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19880523 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19880523 | pubmed:pagination | 54-70 | lld:pubmed |
| pubmed-article:19880523 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
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