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pubmed-article:19880436pubmed:abstractTextSagopilone (ZK-EPO) is a fully synthetic microtubule-stabilizing agent that has demonstrated high antitumor activity in preclinical models. This first-in-human phase I study aimed to determine the maximum tolerated dose (MTD) and dose-limiting toxic effects (DLTs) of 3-weekly sagopilone treatment.lld:pubmed
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pubmed-article:19880436pubmed:articleTitlePhase I study of the novel, fully synthetic epothilone sagopilone (ZK-EPO) in patients with solid tumors.lld:pubmed
pubmed-article:19880436pubmed:affiliationHammersmith Early Clinical Trials Unit, Charing Cross Hospital, Imperial College London, London, UK. p.schmid@imperial.ac.uklld:pubmed
pubmed-article:19880436pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19880436pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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