| pubmed-article:19880244 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19880244 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:19880244 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:19880244 | lifeskim:mentions | umls-concept:C0038435 | lld:lifeskim |
| pubmed-article:19880244 | lifeskim:mentions | umls-concept:C0008479 | lld:lifeskim |
| pubmed-article:19880244 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:19880244 | lifeskim:mentions | umls-concept:C0014239 | lld:lifeskim |
| pubmed-article:19880244 | lifeskim:mentions | umls-concept:C0521451 | lld:lifeskim |
| pubmed-article:19880244 | lifeskim:mentions | umls-concept:C0277785 | lld:lifeskim |
| pubmed-article:19880244 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:19880244 | lifeskim:mentions | umls-concept:C0062964 | lld:lifeskim |
| pubmed-article:19880244 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19880244 | pubmed:dateCreated | 2010-3-29 | lld:pubmed |
| pubmed-article:19880244 | pubmed:abstractText | Chondrosarcoma is a malignant primary bone tumor that responds poorly to both chemotherapy and radiation therapy. In the present study, we investigated the anti-cancer effect of a honokiol, an active component isolated and purified from the Magnolia officinalis in human chondrosarcoma cells. Honokiol-induced cell apoptosis in human chondrosarcoma cell lines (including: JJ012 and SW1353) but not primary chondrocytes. Honokiol also induces upregulation of Bax and Bak, downregulation of Bcl-XL and dysfunction of mitochondria in chondrosarcoma cells. Honokiol triggered endoplasmic reticulum (ER) stress, as indicated by changes in cytosol-calcium levels. We also found that honokiol increased the expression and activities of glucose-regulated protein 78 (GRP78) and calpain. Transfection of cells with GRP78 or calpain siRNA reduced honokiol-mediated cell apoptosis in JJ012 cells. Importantly, animal studies have revealed a dramatic 53% reduction in tumor volume after 21days of treatment. This study demonstrates that honokiol may be a novel anti-cancer agent targeting chondrosarcoma cells. | lld:pubmed |
| pubmed-article:19880244 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19880244 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19880244 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19880244 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19880244 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19880244 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19880244 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19880244 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19880244 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19880244 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19880244 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19880244 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19880244 | pubmed:month | May | lld:pubmed |
| pubmed-article:19880244 | pubmed:issn | 1872-7980 | lld:pubmed |
| pubmed-article:19880244 | pubmed:author | pubmed-author:HsuSheng-Feng... | lld:pubmed |
| pubmed-article:19880244 | pubmed:author | pubmed-author:LiuShing-HwaS... | lld:pubmed |
| pubmed-article:19880244 | pubmed:author | pubmed-author:TangChih-Hsin... | lld:pubmed |
| pubmed-article:19880244 | pubmed:author | pubmed-author:SuYi-ChangYC | lld:pubmed |
| pubmed-article:19880244 | pubmed:author | pubmed-author:ChenYing-JuYJ | lld:pubmed |
| pubmed-article:19880244 | pubmed:author | pubmed-author:FongYi-ChinYC | lld:pubmed |
| pubmed-article:19880244 | pubmed:author | pubmed-author:LiTe-MaoTM | lld:pubmed |
| pubmed-article:19880244 | pubmed:author | pubmed-author:LiuJu-FangJF | lld:pubmed |
| pubmed-article:19880244 | pubmed:author | pubmed-author:WuChien-LinCL | lld:pubmed |
| pubmed-article:19880244 | pubmed:copyrightInfo | 2009 Elsevier Ireland Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:19880244 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19880244 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:19880244 | pubmed:volume | 291 | lld:pubmed |
| pubmed-article:19880244 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19880244 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19880244 | pubmed:pagination | 20-30 | lld:pubmed |
| pubmed-article:19880244 | pubmed:meshHeading | pubmed-meshheading:19880244... | lld:pubmed |
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| pubmed-article:19880244 | pubmed:meshHeading | pubmed-meshheading:19880244... | lld:pubmed |
| pubmed-article:19880244 | pubmed:meshHeading | pubmed-meshheading:19880244... | lld:pubmed |
| pubmed-article:19880244 | pubmed:meshHeading | pubmed-meshheading:19880244... | lld:pubmed |
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| pubmed-article:19880244 | pubmed:meshHeading | pubmed-meshheading:19880244... | lld:pubmed |
| pubmed-article:19880244 | pubmed:meshHeading | pubmed-meshheading:19880244... | lld:pubmed |
| pubmed-article:19880244 | pubmed:meshHeading | pubmed-meshheading:19880244... | lld:pubmed |
| pubmed-article:19880244 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:19880244 | pubmed:articleTitle | Honokiol induces cell apoptosis in human chondrosarcoma cells through mitochondrial dysfunction and endoplasmic reticulum stress. | lld:pubmed |
| pubmed-article:19880244 | pubmed:affiliation | Institute of Toxicology, National Taiwan University, Taipei, ROC. | lld:pubmed |
| pubmed-article:19880244 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19880244 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19880244 | lld:pubmed |
