| pubmed-article:19879804 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19879804 | lifeskim:mentions | umls-concept:C0002736 | lld:lifeskim |
| pubmed-article:19879804 | lifeskim:mentions | umls-concept:C0030567 | lld:lifeskim |
| pubmed-article:19879804 | lifeskim:mentions | umls-concept:C2584303 | lld:lifeskim |
| pubmed-article:19879804 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19879804 | pubmed:dateCreated | 2010-2-4 | lld:pubmed |
| pubmed-article:19879804 | pubmed:abstractText | Neuroinflammation is a pathological hallmark in Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS), and is characterized by activated microglia and infiltrating T cells at sites of neuronal injury. In PD and ALS, neurons do not die alone; neuronal injury is non-cell-autonomous and depends on a well-orchestrated dialogue in which neuronally secreted misfolded proteins activate microglia and initiate a self-propagating cycle of neurotoxicity. Diverse populations and phenotypes of CD4(+) T cells crosstalk with microglia, and depending on their activation status, influence this dialogue and promote neuroprotection or neurotoxicity. A greater understanding of the T cell population that mediates these effects, as well as the molecular signals involved should provide targets for neuroprotective immunomodulation to treat these devastating neurodegenerative diseases. | lld:pubmed |
| pubmed-article:19879804 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19879804 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19879804 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19879804 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19879804 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19879804 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:19879804 | pubmed:issn | 1471-4981 | lld:pubmed |
| pubmed-article:19879804 | pubmed:author | pubmed-author:AppelStanley... | lld:pubmed |
| pubmed-article:19879804 | pubmed:author | pubmed-author:BeersDavid... | lld:pubmed |
| pubmed-article:19879804 | pubmed:author | pubmed-author:HenkelJenny... | lld:pubmed |
| pubmed-article:19879804 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19879804 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:19879804 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19879804 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19879804 | pubmed:pagination | 7-17 | lld:pubmed |
| pubmed-article:19879804 | pubmed:meshHeading | pubmed-meshheading:19879804... | lld:pubmed |
| pubmed-article:19879804 | pubmed:meshHeading | pubmed-meshheading:19879804... | lld:pubmed |
| pubmed-article:19879804 | pubmed:meshHeading | pubmed-meshheading:19879804... | lld:pubmed |
| pubmed-article:19879804 | pubmed:meshHeading | pubmed-meshheading:19879804... | lld:pubmed |
| pubmed-article:19879804 | pubmed:meshHeading | pubmed-meshheading:19879804... | lld:pubmed |
| pubmed-article:19879804 | pubmed:meshHeading | pubmed-meshheading:19879804... | lld:pubmed |
| pubmed-article:19879804 | pubmed:meshHeading | pubmed-meshheading:19879804... | lld:pubmed |
| pubmed-article:19879804 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:19879804 | pubmed:articleTitle | T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening? | lld:pubmed |
| pubmed-article:19879804 | pubmed:affiliation | Department of Neurology, Methodist Neurological Institute, The Methodist Hospital Research Institute, The Methodist Hospital, Houston, TX, USA. sappel@tmhs.org <sappel@tmhs.org> | lld:pubmed |
| pubmed-article:19879804 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19879804 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:19879804 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19879804 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19879804 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19879804 | lld:pubmed |
